Male contraception properties of a new synthetic steroid derivative (danazol) in Rattus rattus rufescens.

V.P. Dixit, Manish Agrawal, Meena Varma
In: Endokrinologie · 1981 · vol. 77(1) , pp. 30–8 · PMID:6164548 · W28426701
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Chronic danazol administration in rats caused testicular lesions, reduced sperm counts, impaired Leydig cell function, inhibited nucleic acid and protein synthesis, and altered cholesterol and enzyme levels, reversibly inhibiting spermatogenesis and steroidogenesis.

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Abstract

Chronic administration of Danazol (25 mg/kg body wt) caused lesions in the testes of Rattus rattus Rufescens. Depletion of spermatocytes, spermatids and spermatozoa was conspicuous. Impairment of Leydig cell function was correlated with reduced cell size and depressed accessory sex organ weights. Epididymal cell height was greatly reduced. The lumen was devoid of spermatozoa. Danazol administration inhibited the synthesis of RNA, protein, sialic acid in the testes and accessory sex organs. Total cholesterol of the testes was increased, whereas the acid phosphatase enzyme activity was reduced. Testosterone propionate did not enhance the growth of accessory sex organs in castrated rats receiving Danazol. In conclusion, Danazol inhibits the system of steroidogenesis and spermatogenesis in Rattus rattus, when treated chronically for a period of 40 days. These effects are reversible after 60 days of cessation of drug administration.

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