Jacob A. Canick — Endo Lab

article 1980

Danazol inhibits human adrenal 21-and 11β-hydroxylation invitro

·doi:10.1016/0039-128x(80)90038-0

The effects of danazol on steroidogenesis in vitro in the 16-20 week old human fetal adrenal were examined by studying: 1) danazol binding to adrenal microsomal and mitochondrial cytochrome P-450, and 2) enzyme kinetics of danazol inhibitio…

article 1977

Danazol Inhibits Steroidogenesis

·doi:10.1016/s0015-0282(16)42732-9

Danazol was found to inhibit multiple enzymes of steroidogenesis directly in the pregnant mare serum (PMS)-treated hamster ovary and the rat testis and adrenal in vitro. In the PMS-treated hamster ovary, danazol inhibited 17alpha-hydroxylas…

article 1977

Danazol Inhibits Steroidogenesis in the Rat Testisin Vitro

·doi:10.1210/endo-101-6-1676

The effects of danazol on steroidogenesis in vitro in the rat testis were examined by studying: 1) androgen synthesis in rat Leydig cells cultured with danazol, 2) danazol binding to rat testis microsomal cytochrome P-450, and 3) enzyme kin…