Endometriosis: What is the Influence of Immune Cells?

Crispim PCA, Paula Carolina Arvelos Crispim, Jammal MP, Millena Prata Jammal, Eddie Fernando Candido Murta, Eddie Fernando Cândido Murta, Rosekeila Simões Nomelini
Immunological investigations · 2020 · vol. 50(4) , pp. 372–388 · doi:10.1080/08820139.2020.1764577 · PMID:32408782 · W3025235379
article OA: closed CC0 ⤵ 20 in-corpus citations
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This review of 100 articles explores the significant role of immune cells and endocrine-immunological interactions in the initiation and progression of endometriosis, suggesting potential new therapeutic targets.

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Abstract

Background: Endometriosis does not have a well-established physiopathology. It has been addressed that endometriosis is an inflammatory disease, where endocrine-immunological interactions are probably involved in the pathogenesis of the disease. The role of the immune system in endometriosis has been suggested to play an important role in both initiation and progression of the disease.Methods: A search for the following keywords was performed in the PubMed database: “endometriosis”, “endometriosis and ovarian cancer”, “endometriosis and immunology”, and “endometriosis and cytokines”.Results: The articles identified were published in English between 1921 and 2020. We selected 100 articles for further analysis.Conclusion: The recognition of the direct involvement of these two important physiological mechanisms causes a change in the pathophysiological focus of the disease. Researching the activities of numerous cells involved in immune reactions may offer new therapeutic targets.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Female Humans Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (94)

Cited by (23)

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europepmc
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