Angiogenesis: a new theory for endometriosis

D. Healy, D L Healy, Healy DL, Peter A. W. Rogers, P A Rogers, Hii L, L Hii, Mary Wingfield, M Wingfield
Human Reproduction Update · 1998 · vol. 4(5) , pp. 736–740 · doi:10.1093/humupd/4.5.736 · PMID:10027628 · W2146205715
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This paper reviews evidence suggesting that excessive endometrial angiogenesis, characterized by enhanced endothelial cell proliferation and increased integrin alphavbeta3 expression, is a key factor in endometriosis pathogenesis.

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Abstract

Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis. Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity. Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alphavbeta3 is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women. Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases. Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy. Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Neovascularization, Pathologic Neovascularization, Pathologic Cell Division Cell Division Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Endothelium, Vascular Endothelium, Vascular Endothelium, Vascular Endothelium, Vascular Female Female Gene Expression Regulation

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (34)

Cited by (50)

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