Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α) as a Regulator of the Angiogenic Profile of Endometriotic Lesions

Vasilios Pergialiotis, Maximos Frountzas, Zacharias Fasoulakis, George Daskalakis, Mairi Chrisochoidi, Konstantinos Kontzoglou, Δέσποινα Περρέα, Despoina N Perrea
Cureus · 2022 · vol. 14(2) , pp. e22616 · doi:10.7759/cureus.22616 · PMID:35371629 · PMC8958147 · W4214723448
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This article reviews evidence suggesting peroxisome proliferator-activated receptor alpha (PPAR-α) agonists downregulate angiogenesis in endometriotic lesions by altering anti-angiogenic molecule expression.

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Abstract

Endometriosis is a disease that affects a significant proportion of women and its infiltrative pattern is entirely dependent on the vascular supply of lesions. Several factors seem to trigger the process of angiogenesis in endometriotic lesions. During the last years, peroxisome proliferator-activated receptors (PPARs), a group of nuclear proteins that regulate gene transcription and that seem to regulate energy consumption and expenditure, have been also implicated in the pathophysiology of angiogenesis. Their ability to regulate the course of cancer and improve the survival rates of patients has been extensively studied and seems to be partially dependent on alteration of the vascular supply of malignant lesions. Research in the field of endometriosis is scarce in the international literature and mainly focused on PPAR-gamma. However, indirect evidence suggests that PPAR-alpha (PPAR-α) may also regulate the vascular supply of endometriotic lesions as well. Specifically, PPAR-α agonists seem to downregulate angiogenesis by increasing the expression of several anti-angiogenic molecules, including thrombospondin-1 (TSP-1) and gypenoside 140 (gp140), as well as factors that are involved in the mitogen-activated protein kinase cascade. In the present article, we summarize existing indirect and direct evidence that indicates the existence of an association between the expression of PPAR-α and endometriosis to help future research in this field.

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endometriosis

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