Mitigation of endometriosis using regenerative cerium oxide nanoparticles

Koel Chaudhury, Narendra Babu K, Abhay K Singh, Babu K N, Singh AK, Soumen Das, Das S, Amit Kumar, Sudipta Seal, Kumar A
Nanomedicine : nanotechnology, biology, and medicine · 2012 · vol. 9(3) , pp. 439–448 · doi:10.1016/j.nano.2012.08.001 · PMID:22960424 · W2128802900
article OA: green CC0 ⤵ 15 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-13 ⓘ

This study demonstrates that cerium oxide nanoparticles mitigate endometriosis lesions in mice by decreasing oxidative stress and inhibiting angiogenesis, while also protecting oocytes from endometriosis-related damage.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

The paper investigated whether regenerative cerium oxide nanoparticles (nanoceria), which scavenge reactive free radicals, can mitigate endometriosis-related pathology. Using a mouse model, the study reported decreased oxidative stress and inhibition of angiogenesis, alongside mitigation of endometrial lesions. It also reported that nanoceria protected oocytes exposed to endometriosis-related adverse effects, assessed in part with visualization methods and including living human oocyte observations, with the major caveat that the evidence for efficacy is based on a murine model. This paper is centrally about endometriosis — it tests nanoceria for reducing oxidative stress, suppressing angiogenesis, and mitigating endometriosis lesions in mice.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Cerium oxide nanoparticles (nanoceria) have recently received attention from the scientific community due to their unique free radicals (specially superoxide radical and hydrogen peroxide) scavenging property in biological system, both in vitro and in vivo. It is suggested that free radicals play an important role in the pathogenesis of endometriosis. In this study we have shown that nanoceria mitigate the endometrial lesions induced in mice model by decreasing oxidative stress and inhibiting angiogenesis. Moreover, nanoceria were also observed to protect endometriosis-related adverse effects on the oocytes, which is critical for successful pregnancy. Summarizing, nanoceria have shown promising efficacy against endometriosis related pathogenesis.From the clinical editorFree radicals have been implemented in the pathogenesis of endometriosis. In a murine model the authors demonstrated successful treatment of endometriosis with nanoceria, and protection of endometriosis-related adverse effects on the oocytes, paving the way to potential clinical translational applications in the future.
Full text 2,062 characters · extracted from oa-html · 2 sections · click to expand

Keywords

Cerium oxide nanoparticles; Antioxidant; Endometriosis; Anti-angiogenesis; LIVING HUMAN OOCYTES; OXIDATIVE-STRESS; MEIOTIC SPINDLE; MOUSE MODEL; ANTIOXIDANT; POLSCOPE; WOMEN; CARDIOMYOPATHY; VISUALIZATION; ANGIOGENESIS; Nanoscience & Nanotechnology; Medicine, Research & Experimental

Abstract

Cerium oxide nanoparticles (nanoceria) have recently received attention from the scientific community due to their unique free radicals (specially superoxide radical and hydrogen peroxide) scavenging property in biological system, both in vitro and in vivo. It is suggested that free radicals play an important role in the pathogenesis of endometriosis. In this study we have shown that nanoceria mitigate the endometrial lesions induced in mice model by decreasing oxidative stress and inhibiting angiogenesis. Moreover, nanoceria were also observed to protect endometriosis-related adverse effects on the oocytes, which is critical for successful pregnancy. Summarizing, nanoceria have shown promising efficacy against endometriosis related pathogenesis. From the Clinical Editor: Free radicals have been implemented in the pathogenesis of endometriosis. In a murine model the authors demonstrated successful treatment of endometriosis with nanoceria, and protection of endometriosis-related adverse effects on the oocytes, paving the way to potential clinical translational applications in the future. (C) 2013 Elsevier Inc. All rights reserved. Journal Title Nanomedicine-Nanotechnology Biology and Medicine Volume 9 Issue/Number 3 Publication Date 1-1-2013 Document Type Article Language English First Page 439 Last Page 448 WOS Identifier ISSN 1549-9634 Recommended Citation "Mitigation of endometriosis using regenerative cerium oxide nanoparticles" (2013). Faculty Bibliography 2010s. 3780. https://stars.library.ucf.edu/facultybib2010/3780

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Cerium Endometriosis Nanoparticles Animals Antigens, CD34 Antigens, CD34 Antioxidants Antioxidants Biomarkers Biomarkers Cell Line Cerium Cerium Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (45)

Cited by (15)

Source provenance

europepmc
last seen: 2026-07-27T06:15:28.040536+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:16:04.919516+00:00
License: CC0 · commercial use OK