Peritoneal fluid in patients with and without endometriosis: prostanoids and macrophages and their effect on the spermatozoa penetration assay
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This study investigated the effects of peritoneal fluid prostanoids and macrophages on sperm penetration through cervical mucus in patients with and without endometriosis.
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Abstract
Peritoneal fluid from 35 women with endometriosis and from 34 control women was aspirated at laparoscopy and analyzed. No differences in prostanoid levels were found. The peritoneal fluid volume, macrophage concentration, macrophage content, and content of activated macrophages as measured by acid phosphatase staining were all significantly elevated in the endometriosis patients. The macrophages were incubated and the medium was added to the zona-free hamster egg sperm penetration assay. This medium caused a significant decrease in the percentage of ova penetrated in this assay. It is postulated that one of the mechanisms of infertility in women with endometriosis may involve the increased number of activated macrophages and their ability to interfere with sperm-egg interaction.
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References (16)
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Cited by (50)
- The role of IL-33/ST2 signaling in female reproductive diseases 2026
- Rediscovering peritoneal macrophages in a murine endometriosis model 2016
- Endometriotic Epithelial Cell Response to Macrophage-Secreted Factors is Dependent on Extracellular Matrix Context 2014
- Pathophysiology of Infertility in Endometriosis 2011
- Endometriosis and inflammation in infertility 2004
- Endometriosis and inflammation in infertility 2004
- Role of IL-18 in pathogenesis of endometriosis 2004
- Diagnosis and treatment of endometriosis 2003
- Endometriosis: an overview of the disease and its treatment 2000
- Effect of peritoneal fluid from women with endometriosis on implantation in the mouse model 2000
- The relevance of the peritoneal fluid in endometriosis-associated infertility 1999
- Immunology of endometriosis 1999
- Peritoneal fluid modulates the sperm acrosomal exocytosis induced by N-acetylglucosaminyl neoglycoprotein 1999
- Effect of peritoneal fluid from endometriosis patients on sperm motion characteristics and acrosome reaction 1999
- Pathophysiology of endometriosis-associated infertility 1999
- Functional and phenotypic alterations in peritoneal macrophages from patients with early and advanced endometriosis 1998
- Endometriosis-associated infertility 1997
- Pathophysiology. The biologic principles of disease 1997
- Chemotaxis of macrophages by a peritoneal fluid protein in women with endometriosis 1997
- Pathogenesis of endometriosis 1997
- Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility 1997
- Transferrin receptor (CD71) expression in peritoneal macrophages from fertile and infertile women with and without endometriosis 1997
- The peritoneal environment in endometriosis 1996
- The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro 1996
- Immunological aspects of endometriosis 1996
- PGE2 and PGF2 alpha release by human peritoneal macrophages in endometriosis 1996
- Review of Peritoneal Factors that Affect Fertility in Patients With Mild Endometriosis 1996
- Peritoneal fluid from women with moderate or severe endometriosis inhibits sperm motility: the role of seminal fluid components 1996
- In vitro fertilization/embryo transfer in unexplained infertility and minimal peritoneal endometriosis 1995
- The effect of serum from infertile women with endometriosis on fertilization and early embryonic development in a murine in vitro fertilization model 1995
- Pathogenesis of Infertility in Endometriosis 1995
- Treatment of Infertility Associated With Endometriosis 1995
- An elicited intraperitoneal inflammatory response has no effect on the establishment of pregnancy in the mouse 1994
- The role of macrophage colony stimulating factor in the peritoneal fluid in infertile patients with endometriosis 1994
- Endometriosis: Immune Cells and Their Products 1994
- Adverse effects on sperm movement characteristics in women with minimal and mild endometriosis 1993
- Inflammatory reaction in endometriotic tissue: an immunohistochemical study 1993
- Effects of peritoneal fluids from patients with endometriosis on capacitated spermatozoa 1993
- Endometriosis and luteal phase defect 1993
- Hysterosalpingography contrast media and chromotubation dye inhibit peritoneal lymphocyte and macrophage function in vitro: a potential mechanism for fertility enhancement 1993
- Oily contrast medium as a therapeutic agent for infertility because of mild endometriosis 1993
- Endometriosis-associated infertility 1993
- Pretreatment with gonadotrophin releasing hormone (GnRH) analogue prior to in vitro fertilisation for patients with endometriosis 1993
- The effect of preovulatory peritoneal fluid from cases of endometriosis on murine in vitro fertilization, embryo development, oviduct transport, and implantation 1992
- In vitro lymphocyte activity in women with endometriosis--an altered immune response? 1992
- IL6 and acute phase plasma proteins in peritoneal fluid of women with endometriosis 1992
- The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro 1992
- Correlation between dysmenorrheic severity and prostaglandin production in women with endometriosis 1992
- Pathogenesis of endometriosis 1992
- The peritoneal environment in endometriosis 1991
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