Effect of tumor necrosis factor-alpha on adhesion of human endometrial stromal cells to peritoneal mesothelial cells: an in vitro system

Zhang RJ, Renjie Zhang, R J Zhang, R A Wild, Wild RA, Robert A. Wild, James M. Ojago, J M Ojago, Ojago JM
Fertility and sterility · 1993 · vol. 59(6) , pp. 1196–1201 · doi:10.1016/s0015-0282(16)55976-7 · PMID:8495765 · W2401679371
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Tumor necrosis factor-α was investigated for its effect on the adhesion of human endometrial stromal cells to peritoneal mesothelial cells in an in vitro system.

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Abstract

OBJECTIVE: To assess the effects of tumor necrosis factor-alpha (TNF-alpha) on adhesion of endometrial stromal cells to peritoneal mesothelial cells, a possible step leading to endometriosis. DESIGN: Analysis of cell adhesion in vitro. SETTING: University research laboratory. PATIENTS: Peritoneal fluid and biopsies were obtained from volunteers with regular cycles without endometriosis or endometrial pathology. INTERVENTIONS: Tumor necrosis factor-alpha (0.1 to 1,000 U/mL) was added to nutrient media with the following supplements: 10% fetal calf serum, epidermal growth factor 20 ng/mL, and gentamicin 10 ng/mL. MAIN OUTCOME MEASURES: Radioactivity of chromium-51 was used as a reflection of adherent stromal cells. RESULTS: The adherence of endometrial stromal cells to mesothelial cells was significantly increased by pretreatment of mesothelial cells with TNF-alpha. CONCLUSIONS: Tumor necrosis factor-alpha may play a facilitory role in the development of endometriosis.

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MeSH descriptors

Endometrium Peritoneal Cavity Stromal Cells Tumor Necrosis Factor-alpha Cell Adhesion Cell Adhesion Cell Adhesion Cells, Cultured Cells, Cultured Endometrium Endometrium Endometrium Epithelial Cells Epithelial Cells Female Female Humans Humans Peritoneal Cavity Peritoneal Cavity

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