Advances in the management of endometriosis: an update for clinicians

Crosignani P, PierGiorgio Crosignani, David L. Olive, David Olive, Olive D, Agneta Bergqvist, Bergqvist A, Anthony A. Luciano, Luciano A, Anthony Luciano
Human Reproduction Update · 2005 · vol. 12(2) , pp. 179–189 · doi:10.1093/humupd/dmi049 · PMID:16280355 · W2141979474
Review OA: bronze CC0 ⤵ 189 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This review updates clinicians on endometriosis management, discussing current pharmacologic therapies like COCs, danazol, and GnRH analogues, and exploring newer treatment options for symptom relief.

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Abstract

Endometriosis is a chronic and recurrent disease characterized by the presence and proliferation of endometrial tissue outside the uterine cavity, which occurs in approximately 10% of women of reproductive age. In this estrogen-dependent disorder, lesions become inactive and gradually undergo regression during states of ovarian down-regulation, such as amenorrhoea or menopause. The impact of endometriosis includes impaired fertility potential, as well as symptoms of dysmenorrhoea, dyspareunia and chronic non-menstrual pain, all of which adversely affect quality of life. Management of endometriosis focuses on pain relief and includes medical and surgical treatment. Pharmacologic therapies currently in use include combination oral contraceptives (COCs), danazol, GnRH analogues and progestins. Although some agents show efficacy in relieving pain, all differ in their side effects, making it difficult to achieve a balance between efficacy and safety. Efficacy has been demonstrated with danazol or GnRH analogues; however, treatment is limited to 6 months because of significant metabolic side effects. Alternatives for longer-term management of symptoms include add-back therapy with GnRH analogues, COCs or progestins. Newer options for treatment of endometriosis include depot medroxyprogesterone acetate subcutaneous injection, as well as several agents under investigation that may prove to have therapeutic potential.

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Condition tags

endometriosisdysmenorrheadyspareunia

MeSH descriptors

Endometriosis Endometriosis Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Contraceptives, Oral, Combined Contraceptives, Oral, Combined Contraceptives, Oral, Combined Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis Estrogen Receptor Modulators Estrogen Receptor Modulators Estrogen Receptor Modulators Estrogen Receptor Modulators Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (96)

Cited by (50)

Source provenance

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