Short-term Efficacy of Dienogest in Improving Pain in Patients with Endometriosis: A Single-center Experience

Cihan Kaya, İsmail Alay, Hüseyin Cengiz, Ece Bahçeci, Murat Ekin, Levent Yaşar
In: European Archives of Medical Research · 2021 · vol. 37(1) , pp. 11–14 · doi:10.4274/eamr.galenos.2019.76376 · W3133429359
article OA: bronze CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study evaluated dienogest's effect on improving pain scores in patients diagnosed with endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-15 · read from full text ⓘ

This single-center study evaluated the short-term efficacy of dienogest (DNG) for pain in 77 women attending an endometriosis clinic (March 2015 to March 2017), comparing a DNG group (n=46) versus an expectant management group that denied other medications (n=31). Pain symptoms were assessed using visual analog scale (VAS) scores, with baseline characteristics (age, parity, gravidity, BMI, VAS scores, and further surgery requirement) reported as not significantly different between groups. After 6 months, the DNG group showed significantly greater reductions in VAS scores for dysmenorrhea, dyspareunia, dyschezia, and overall pelvic pain, with p-values of <0.001, 0.04, 0.009, and 0.01, respectively. This paper is centrally about endometriosis — it directly assesses dienogest’s effect on improving multiple pain symptoms in women with endometriosis.

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Abstract

Objective: Endometriosis is a common disease that affects 5%-15% of women of reproductive age. This study aimed to evaluate the effect of dienogest (DNG) on improving pain scores of patients with endometriosis.
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Abstract

Objective: Endometriosis is a common disease that affects 5%-15% of women of reproductive age. This study aimed to evaluate the effect of dienogest (DNG) on improving pain scores of patients with endometriosis.

Methods

Data of 77 women who were admitted to the endometriosis clinic from March 1, 2015, to March 1, 2017, were evaluated. Patients were divided into 2 groups: DNG group (n=46) or group that denied use of any medication (expectant management group, n=31). The main presenting symptoms were graded using the visual analog scale (VAS). Age, parity, gravidity, body mass index (BMI), VAS scores, and further surgery requirement of the study groups were compared.

Results

The most common presenting symptom was dysmenorrhea (79.2%), and the least common was dysuria (7.8%). No statistically significant difference was found between the study groups in terms of age, parity, gravidity, BMI, and further surgery requirement. A significant difference was found in the reduction of dysmenorrhea, dyspareunia, dyschezia, and pelvic pain VAS scores between the study groups, and more reduction was observed in the DNG group after 6 months of follow-up (p<0.001, p=0.04, p=0.009, and p=0.01, respectively).

Conclusion

DNG might be an alternative treatment for reducing pain symptoms related to endometriosis.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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