Leuprorelin acetate depot vs danazol in the treatment of endometriosis: results of an open multicentre trial.
article
OA: closed
CC0
⤵ 21 in-corpus citations
AI-generated summary
This trial compared leuprorelin acetate depot and danazol in 67 endometriosis patients, finding both effective with leuprorelin providing significantly better pain control.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
A national multicentre trial was organized in order to compare the efficacy and safety of leuprorelin acetate depot and danazol in the treatment of endometriosis. Sixty-seven patients with pelvic endometriosis of different severity at laparoscopy were included in the study and followed during the 24 weeks of treatment. Leuprorelin acetate depot 3.75 mg was injected every 24 days, while the daily dose of danazol was 600-800 mg. At the end of the study objective improvements induced by the two drugs were observed by a second laparoscopic examination. In addition, at regular intervals during the study semiquantitative evaluation of subjective symptoms were monitored. Scoring the final objective changes in the two patient groups revealed no significant difference, however the women treated with leuprorelin acetate depot registered significantly better control of pelvic pain. Due to its efficacy, tolerability and ease of use, leuprorelin acetate appears to be an excellent drug for the treatment of endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
Cited by (21)
- Endometriosis in Adolescent Girls 2020
- RETIRED: No 164 - Directive clinique de consensus pour la prise en charge de la douleur pelvienne chronique 2018
- RETIRED: No. 164-Consensus Guidelines for the Management of Chronic Pelvic Pain 2018
- Ovarian hormones and chronic pain: A comprehensive review 2014
- Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report 2012
- Innovations in conservative endometriosis treatment: an updated review. 2011
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Medikamentöse Schmerztherapie der Endometriose 2008
- Management of the Pain Associated with Endometriosis: An Update of the Painful Problems 2006
- RETIRED: Directive clinique de consensus pour la prise en charge de la douleur pelvienne chronique 2005
- Advances in the management of endometriosis: an update for clinicians 2005
- Optimizing Gonadotropin-Releasing Hormone Agonist Therapy in Women with Endometriosis 2004
- Tratamiento de la endometriosis y medicina basada en la evidencia 2003
- Consensus statement for the management of chronic pelvic pain and endometriosis: proceedings of an expert-panel consensus process 2002
- The Treatment of Endometriosis 2002
- Medical and Surgical Therapies for Pain Associated with Endometriosis 2001
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Chronic pelvic pain in women - gastroenterological, gynaecological or psychological? 1997
- Laparoscopic treatment of symptomatic endometriosis 1996
- Medical management of endometriosis 1993
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:11:54.876058+00:00
License: CC0
· commercial use OK