The Etonogestrel Contraceptive Implant as a Therapy for Endometriosis

In: ISGE Series · 2020 · pp. 65–71 · doi:10.1007/978-3-030-57866-4_7 · W3112890699
book-chapter OA: closed CC0 ⤵ 2 in-corpus citations
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06+body, 2026-06-07

This study examined the use of the etonogestrel contraceptive implant for treating endometriosis, a chronic estrogen-dependent gynecological disease.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text

This paper reviews endometriosis as an estrogen-dependent inflammatory disorder characterized by ectopic endometrial tissue and discusses the etonogestrel-releasing contraceptive implant in the context of endometriosis management, drawing on prior clinical experience and published studies. Across the cited literature included in the chapter, the implant is presented as a hormonal option evaluated for endometriosis-associated pelvic pain and related quality-of-life outcomes, with attention to tolerability and bleeding profile considerations. The chapter’s main limitation is that it is not a single original study and relies on heterogeneous evidence from prior reports rather than providing new pooled trial results. This paper is centrally about endometriosis — it specifically frames the etonogestrel contraceptive implant as a therapy within endometriosis pathogenesis and clinical management.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 6,604 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

Endometriosis is a chronic estrogen-dependent gynecological disease characterized by the presence of endometrial tissue (stroma and/or glands) outside the uterine cavity, which induces a chronic, inflammatory reaction. Most commonly this involves ovaries and fallopian tubes, and rarely endometrial tissue may spread beyond pelvic organs. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Viganò P, Parazzini F, Somigliana E, Vercellini P. Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol. 2004;18:177–200. The Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility. Fertil Steril. 2006;86(Suppl 4):S15660. Koga K, Takamura M, Fujii T, Osuga Y. Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis. Fertil Steril. 2015;104:793–801. Crosignani PG, Olive D, Bergqvist A, Luciano A. Advances in the management of endometriosis: an update for clinicians. Hum Reprod Update. 2006;12:179–89. Dunselman GAJ, Vermeulen N, Becker C, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29:400–12. https://doi.org/10.1093/humrep/det457. Ferrero S, Abbamonte LH, Giordano M, et al. Deep dyspareunia and sex life after laparoscopic excision of endometriosis. Hum Reprod. 2007;22:1142–8. Vercellini P, De Giorgi O, Mosconi P, et al. Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis. Fertil Steril. 2002;77:52–61. Muneyyirci-Delale O, Anopa J, Charles C, Mathur D, Parris R, Cutler JB, Salame G, Abulafi O. Medical management of recurrent endometrioma with long-term norethindrone acetate. Int J Women’s Health. 2012;4:149–54. Kohler G, Faustmann TA, Gerlinger C, Seitz C, Mueck AO. A dose-ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis. Int J Gynaecol Obstet. 2010;108(1):21–5. Harada T, Momoeda M, Taketani Y, et al. Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis–a randomized, doubleblind, multicenter, controlled trial. Fertil Steril. 2009;91(3):675–81. Del Forno S, Mabrouk M, Arena A, Mattioli G, Giaquinto I, Paradisi R, Seracchioli R. Dienogest or norethindrone acetate for the treatment of ovarian endometriomas: can we avoid surgery? Eur J Obstet Gynecol Reprod Biol. 2019;238:120–4. Fedele L, Bianchi S, Zanconato G, et al. Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis. Fertil Steril. 2001;75:485–8. Blumenthal PD, Gemzell-Danielsson K, Marintcheva-Petrova M. Tolerability and clinical safety of Implanon®. Eur J Contracept Reprod Health Care. 2008;13:29. Croxatto HB, Mäkäräinen L. The pharmacodynamics and efficacy of Implanon. An overview of the data. Contraception. 1998;58(6 Suppl):91S97S. Di Carlo C, Sansone A, De Rosa N, Gargano V, Tommaselli GA, Nappi C, Bifulco G. Impact of an implantable steroid contraceptive (Etonogestrel-releasing implant) on quality of life and sexual function: a preliminary study. Gynecol Endocrinol. 2014;30(1):53–6. Ponpuckdee J, Taneepanichskul S. The effects of implanon in the symptomatic treatment of endometriosis. J Med Assoc Thail. 2005;88(Suppl 2):S7–10, 56 Ferrero S, Scala C, Ciccarelli S, Vellone VG, Barra F. Treatment of rectovaginal endometriosis with the etonogestrel-releasing contraceptive implant. Gynecol Endocrinol. 2019;12:1–5. Yisa SB, Okenwa AA, Husemeyer RP. Treatment of pelvic endometriosis with etonogestrel subdermal implant (Implanon). J Fam Plann Reprod Health Care. 2005;31:67–70. Walch K, Unfried G, Huber J, et al. Implanon® versus medroxyprogesterone acetate: effects on pain scores in patients with symptomatic endometriosis—a pilot study. Contraception. 2009;79:29–34. Sansone A, De Rosa N, Giampaolino P, Guida M, Laganà AS, Di Carlo C. Effects of etonogestrel implant on quality of life, sexual function, and pelvic pain in women suffering from endometriosis: results from a multicenter, prospective, observational study. Arch Gynecol Obstet. 2018;298(4):731–6. Carvalho N, Margatho D, Cursino K, Benetti-Pinto CL, Bahamondes L. Control of endometriosis-associated pain with etonogestrel-releasing contraceptive implant and 52-mg levonorgestrel-releasing intrauterine system: randomized clinical trial. Fertil Steril. 2018;110(6):1129–36. Margatho D, Mota Carvalho N, Eloy L, Bahamondes L. Assessment of biomarkers in women with endometriosis-associated pain using the ENG contraceptive implant or the 52 mg LNG-IUS: a non-inferiority randomised clinical trial. Eur J Contracept Reprod Health Care. 2018;23(5):344–50. Margatho D, Carvalho NM, Bahamondes L. Endometriosis-associated pain scores and biomarkers in users of the etonogestrel-releasing subdermal implant or the 52-mg levonorgestrel-releasing intrauterine system for up to 24 months. Eur J Contracept Reprod Health Care. 2020;18:1–8. Mansour D, Korver T, Marintcheva-Petrova M, Fraser IS. The effects of Implanon on menstrual bleeding patterns. Eur J Contracetp Reprod Health Care. 2008;13(Suppl 1):13–28. Guida M, Visconti F, Cibarelli F, Granozio G, Troisi J, Martini E, Nappi R. Counseling and management of patients requesting subcutaneous contraceptive implants: proposal for a decisional algorithm. Gynecol Endocrinol. 2014;30(7):525–31. Di Carlo C, Guida M, De Rosa N, Sansone A, Gargano V, Cagnacci A, Nappi C. Bleeding profile in users of an etonogestrel subdermal implant: effects of anthropometric variables. An observational uncontrolled preliminary study in Italian population. Gynecol Endocrinol. 2015;31(6):491–4. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2021 International Society of Gynecological Endocrinology About this chapter Cite this chapter Visconti, F., Di Carlo, C. (2021). The Etonogestrel Contraceptive Implant as a Therapy for Endometriosis. In: Genazzani, A.R., Nisolle, M., Petraglia, F., Taylor, R.N. (eds) Endometriosis Pathogenesis, Clinical Impact and Management. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-030-57866-4_7 Download citation DOI: https://doi.org/10.1007/978-3-030-57866-4_7 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-57865-7 Online ISBN: 978-3-030-57866-4 eBook Packages: MedicineMedicine (R0)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK