Angiogenic factors in endometriosis

Robert N. Taylor, Taylor RN, Dan I. Lebovic, Michael D. Mueller
Annals of the New York Academy of Sciences · 2002 · vol. 955(1) , pp. 89–100 · doi:10.1111/j.1749-6632.2002.tb02769.x · PMID:11949968 · W1975413186
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This review examines the cytokines, growth factors, hormones, and eicosanoids driving angiogenesis in endometriosis, suggesting interference with these factors could offer therapeutic benefits.

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Abstract

Similar to tumor metastases, endometriotic implants require neovascularization to establish, grow, and invade. The peritoneal environment is ideally suited to provide a proangiogenic milieu. Nevertheless, endometriotic lesions are found only in a minority of reproductive-age women (approximately 10%) with retrograde menstruation. In this paper, we review the major cytokines, growth factors, steroid hormones, and eicosanoids responsible for angiogenesis in endometriosis. We postulate that interference with angiogenic principles expressed in the peritoneum may constitute novel therapeutic opportunities for the prevention, amelioration, or treatment of pelvic endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Angiogenesis Inducing Agents Endometriosis Angiogenesis Inducing Agents Angiogenesis Inducing Agents Ascitic Fluid Ascitic Fluid Ascitic Fluid Cytokines Cytokines Cytokines Endometriosis Endometriosis Female Female Humans Humans Neovascularization, Pathologic Neovascularization, Pathologic

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (91)

Cited by (50)

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License: CC0 · commercial use OK