Plasma levels of polychlorinated biphenyl, genetic polymorphisms, and the risk of advanced stage endometriosis

Miran Kim, Kim M, Kim SH, Sung Hoon Kim, Hyun Jin Kim, Kim HJ, Dong Hee Whang, Whang DH, Yun SC, Sung-Cheol Yun, Sung‐Cheol Yun, Sa Ra Lee, Lee SR, Chae HD, Hee Dong Chae, Byung Moon Kang, Kang BM
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2020 · vol. 36(7) , pp. 636–640 · doi:10.1080/09513590.2020.1753183 · PMID:32295439 · W3017140390
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This study found higher plasma polychlorinated biphenyl levels in controls and an increased endometriosis risk in women lacking the C/C genotype for AhRR codon 185, suggesting a possible gene-environment interaction.

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Abstract

Both environmental and genetic factors interact and play a critical role in the pathogenesis of endometriosis. We analyzed the plasma levels of 12 polychlorinated biphenyl (PCB) congeners with genetic polymorphisms of glutathione-S-transferase M1 (GSTM1), glutathione-S-transferase T1 (GSTT1), and aryl hydrocarbon receptor repressor (AhRR) codon 185. Total sum of the 12 congeners was significantly higher in the controls compared with endometriosis group. Women without C/C genotype in AhRR codon 185 had a significantly increased risk of endometriosis compared with those with C/C genotype. Total sum of the 12 congeners was significantly higher in women without C/C genotype compared with those with C/C genotype. Adjusting for age and AhRR codon 185 genotype, there was no significant association between exposure to PCBs and the risk of endometriosis. These findings suggest a possible presence of gene-environment interaction, however, we could not see any clear association between exposure to PCBs and the risk of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Ovarian Diseases Ovarian Diseases Ovarian Diseases Ovarian Diseases Ovarian Diseases Polychlorinated Biphenyls Polymorphism, Genetic Adult Basic Helix-Loop-Helix Proteins Basic Helix-Loop-Helix Proteins Case-Control Studies Disease Progression Environmental Exposure Environmental Exposure Environmental Exposure

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