Endometriosis and infertility: epidemiology and evidence-based treatments

Sebiha Özkan, Ozkan S, Sebiha Ozkan, William Murk, Murk W, Aydın Arıcı, Aydin Arici, Arici A
Annals of the New York Academy of Sciences · 2008 · vol. 1127(1) , pp. 92–100 · doi:10.1196/annals.1434.007 · PMID:18443335 · W2109367793
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Endometriosis, a common cause of infertility, is managed surgically, with assisted reproductive technologies recommended based on disease stage and pelvic anatomy.

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Abstract

Endometriosis is an estrogen-dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5-5% in fertile and 25-40% in infertile women. The optimal choice of management for endometriosis-associated infertility remains obscure. Removal or suppression of endometrial deposits by medical or surgical means constitutes the basis of endometriosis management. Current evidence indicates that suppressive medical treatment of endometriosis does not benefit fertility and should not be used for this indication alone. Surgery is probably efficacious for all stages of the disease. Controlled ovarian hyperstimulation with intrauterine insemination is recommended in early-stage and surgically corrected endometriosis when pelvic anatomy is normal. In advanced cases, in vitro fertilization is a treatment of choice, and its success may be augmented with prolonged gonadotropin-releasing hormone analog treatment. Further randomized clinical trials focusing on diverse etiopathogenic mechanisms and therapeutic innovation are necessary to find more conclusive, evidence-based answers regarding this enigmatic disease.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Infertility, Female Infertility, Female Endometriosis Endometriosis Endometriosis Evidence-Based Medicine Evidence-Based Medicine Female Female Fertilization in Vitro Fertilization in Vitro Humans Humans Infertility Infertility Infertility, Female Infertility, Female Infertility, Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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