Endometriosis is associated with a decreased risk of pre-eclampsia

Ivo Brosens, Brosens IA, Ivo A Brosens, Petra De Sutter, De Sutter P, Tjalina Hamerlynck, Lindita Imeraj, Zhan Yao, Yao Z, Cloke B, Brianna Cloke, Brosens JJ, Jan J. Brosens, Dhont M, Marc Dhont
Human Reproduction · 2007 · vol. 22(6) , pp. 1725–1729 · doi:10.1093/humrep/dem072 · PMID:17452394 · W2165117758
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This case-control study found that pregnancies following endometriosis-associated infertility had a significantly lower incidence of pre-eclampsia and pregnancy-induced hypertension compared to pregnancies following male-factor infertility treatment.

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Abstract

BACKGROUND: We postulated that impaired endometrial differentiation in women with pelvic endometriosis predisposes for pre-eclampsia. METHODS: A retrospective case-control study set at the University of Ghent IVF centre. The incidence of pre-eclampsia and pregnancy-induced hypertension (PIH) following the clinical and/or laparoscopic diagnosis of endometriosis-associated infertility (case group; n = 245 pregnancies) was compared with the incidence of these obstetric complications in pregnancies following treatment for male-factor infertility (control group; n = 274 pregnancies). Pregnancy data were obtained by searching electronic databases and postal questionnaires. The case and control groups were matched for age, parity and multiple pregnancies. RESULTS: The incidence of pre-eclampsia was significantly lower in the case group (0.8%) when compared with control group (5.8%) (P = 0.002; odds ratio (OR) = 7.5, 95% confidence interval (CI): 1.7-33.3). Analysis of obstetric outcome in the subgroup of patients with laparoscopic data confirmed the lower risk of pre-eclampsia in the case (1.2%) versus control (7.4%) groups (P = 0.032; OR = 6.6, 95% CI: 1.2-37). PIH occurred in 3.5% and 8.7% of case and control pregnancies, respectively (P = 0.018; OR = 2.6, 95% CI: 1.2-6.0). The odds of developing pre-eclampsia were 5.67 times higher in the control group than in pregnancies following endometriosis-associated infertility. In multiple pregnancies, the odds of developing pre-eclampsia increased 1.93 times per additional child, with or without endometriosis. CONCLUSIONS: We found no evidence that endometriosis predisposes for pre-eclampsia. Instead, the risk of hypertensive disorder in pregnancy is significantly reduced in women with endometriosis-associated infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Pre-Eclampsia Uterine Diseases Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Humans Humans Incidence Incidence Middle Aged Middle Aged Pre-Eclampsia Pre-Eclampsia Pregnancy

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

Cited by (50)

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