Heritability and molecular genetic studies of endometriosis

Joe Leigh Simpson, Bischoff FZ, Farideh Z. Bischoff
Annals of the New York Academy of Sciences · 2002 · vol. 955(1) , pp. 239–251 · doi:10.1111/j.1749-6632.2002.tb02785.x · PMID:11949952 · W2109989839
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This paper reviews the evidence for polygenic/multifactorial inheritance of endometriosis and discusses strategies for identifying causative genes, including a hypothesis of multistep clonal origin similar to neoplasia.

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Abstract

Endometriosis is well established as a condition showing heritable tendencies. Polygenic/multifactorial etiology appears far more likely to be the etiology than Mendelian inheritance. The current task is to determine the number and location of genes responsible for endometriosis. This paper shall review the basis for concluding that endometriosis is a genetic disorder of polygenic/multifactorial inheritance and outline selected strategies for identifying the number and location of causative genes. It shall also illustrate our approach to testing the hypothesis that endometriosis bears similarity to neoplasia and, hence, is a multistep phenomenon of clonal origin.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease DNA DNA DNA Endometriosis Endometriosis Female Female Gene Expression Gene Expression Genetic Linkage Genetic Linkage Humans Humans Oncogenes Oncogenes Quantitative Trait, Heritable Quantitative Trait, Heritable

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (79)

Cited by (50)

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