Assessment of endometrial receptivity

Bruce A. Lessey, Lessey BA
Fertility and sterility · 2011 · vol. 96(3) , pp. 522–529 · doi:10.1016/j.fertnstert.2011.07.1095 · PMID:21880273 · W2134982308
Review OA: bronze CC0 ⤵ 35 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper investigates endometrial receptivity by analyzing specific molecular markers and gene expression patterns within the uterine lining.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To provide a focused review of the scientific literature pertaining to endometrial receptivity. DESIGN: Review of the literature and appraisal of relevant articles. SETTING: Academic teaching hospital. PATIENT(S): Women with infertility. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Critical review of the literature. RESULT(S): Although a consensus has been achieved regarding the existence of a temporally defined period during which embryo attachment and invasion can occur (called the "window of implantation"), reliable methods to assess "receptivity" have not been established or adequately validated. In women with certain gynecologic disorders, including endometriosis, tubal disease, and polycystic ovary syndrome, endometrial receptivity seems to be compromised, leading to infertility and pregnancy loss. The establishment of reliable biomarkers for the detection of defects in endometrial receptivity has been a long-sought goal that remains an elusive target. The validation of endometrial biomarkers will require properly designed and implemented studies based on the recognition that endometrial receptivity defects are not equally distributed in women with endometriosis or these other conditions. CONCLUSION(S): Rapidly advancing technologies are bringing new biomarkers to the clinical arena that promise to further reveal the complexities of the implantation process.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Embryo Implantation Endometriosis Endometrium Infertility, Female Biomarkers Biomarkers Biomarkers Embryo Implantation Embryo Implantation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Humans Humans Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (34)

Source provenance

europepmc
last seen: 2026-10-11T09:27:45.537177+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:09:19.025198+00:00
License: CC0 · commercial use OK