Comparison of Endometrial Receptivity Markers Between Women with Polycystic Ovary Syndrome, Endometrioma and Unexplained Subfertility: A Cross-Sectional Study

Emine DEMİR, Fulya Oğuz Türkyılmaz, Mustafa Şengül, Sefa KELEKÇİ
In: Journal of Clinical Obstetrics & Gynecology · 2022 · vol. 32(3) , pp. 77–84 · doi:10.5336/jcog.2022-89394 · W4312366933
article OA: bronze CC0
📄 Open PDF View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study compared endometrial receptivity markers (IGFBP1, OPN, PGE2) in women with PCOS, endometrioma, and unexplained subfertility, finding no differences except for higher PGE2 in PCOS patients compared to controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This cross-sectional prospective study compared concentrations of endometrial receptivity markers IGFBP-1, osteopontin (OPN), and prostaglandin E2 (PGE2) in uterine flushing fluid collected during the midluteal implantation window among ovulatory women with polycystic ovary syndrome (PCOS), endometrioma, unexplained subfertility, and ovulatory fertile controls. Using progesterone-confirmed ovulation and ELISA assays, the authors found no significant differences in IGFBP-1, OPN, or most marker comparisons across groups, but PGE2 was significantly higher in the PCOS group than in healthy controls. The study’s main limitation is that it did not demonstrate differences for IGFBP-1 or OPN and relied on cross-sectional endometrial fluid measurements without pregnancy outcome tracking. This paper is centrally about endometriosis — it compares endometrioma patients as a condition alongside PCOS and subfertility to assess endometrial receptivity markers.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Objective: Uterine receptivity and implantation are complex processes that require the coordinated expression of molecules by the zygote and uterus. Some molecules have been identified at different stages of the luteal phase as receptivity markers that play roles in implantation. This cross-sectional prospective study aimed to compare the levels of insulin-like growth factor binding protein 1 (IGFBP 1), osteopontin (OPN) and prostaglandin E2 (PGE2) in endometrial flushing liquid during the midluteal phase between patients diagnosed with polycystic ovary syndrome (PCOS), endometrioma and unexplained subfertility, and ovulatory women. Material and Methods: The study groups were formed by women with ovulatory PCOS (n=24), endometrioma (n=17) and unexplained subfertility (n=25). The control group consisted of fertile women (n=18). During the implantation window, endometrial flushing samples were taken and IGFBP1, OPN and PGE2 levels were analyzed and compared among the groups. Results: There were no significant differences in the levels of IGFBP1, PGE2 and OPN among groups. PGE2 levels were 367.7±96.3 ng/mL and 239.2±106.9 ng/mL in women with PCOS and in healthy women, respectively. This difference was statistically significant (p=0.002). The present results show that PGE2 might be an indicator of unfavorable endometrial receptivity and might be responsible for the low pregnancy rates in patients with PCOS. Conclusion: We hypothesized that PGE2 downregulation may facilitate decidualization and improve the pregnancy rate in ovulatory PCOS. So, this can guide us about future treatment in the management of patients.

My notes (saved in your browser only)

Condition tags

endometrioma

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

References (27)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK