Analysis of cytokines in the peritoneal fluid of endometriosis patients as a function of the menstrual cycle stage using the Bio-Plex® platform
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This study compared peritoneal fluid cytokine levels in women with and without endometriosis across menstrual cycle phases, identifying IL-6, IL-18, and MCP-1 as potential endometriosis biomarkers.
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Abstract
OBJECTIVE: Endometriosis is a painful disease affecting 10-15% of reproductive-age women. Concentrations of several cytokines and angiogenic factors in peritoneal fluid (PF) have been found to correlate with the severity of the disease. However, levels of some analytes vary across the menstrual cycle, and an ideal biomarker of endometriosis has not yet been identified. We have compared the PF concentrations of different cytokines in proliferative and secretory phases in women with and without the disease using the Bio-Plex platform.
METHODS: PF was aspirated during laparoscopy (N = 133) and the PF concentrations of 18 cytokines from Bio-Plex panels I and II determined with the serum protocol.
RESULTS: Increased PF concentrations of IL-6, IL-18, eotaxin, and MCP-1 were found in endometriosis with no changes with menstrual cycle. Levels of IL-12(p70), ICAM-1, and GRO-α were higher in the secretory phase, while eotaxin concentrations were lower.
CONCLUSION: Of the 18 cytokines tested, IL-6, IL-18 and MCP-1 were the best PF markers of endometriosis.
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- An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review 2024
- Changes in MCP-1, HGF, and IGF-1 expression in endometrial stromal cells, PBMCs, and PFMCs of endometriotic women following 1,25(OH)2D3 treatment 2022
- The Role of Selected Chemokines in the Peritoneal Fluid of Women with Endometriosis—Participation in the Pathogenesis of the Disease 2021
- Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review 2021
- Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes 2020
- Characterizing the endometrial fluid cytokine profile in women with endometriosis 2020
- Biomarkers for Endometriosis in Saliva, Urine, and Peritoneal Fluid 2017
- Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis 2017
- Avaliação da participação dos <i>Mollicutes</i> e outros microrganismos de interesse genital na endometriose humana. 2017
- Endometriosis-associated changes in serum levels of interferons and chemokines 2017
- Endometriosis: where are we and where are we going? 2016
- Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women 2016
- PRL-3 Is Involved in Estrogen- and IL-6-Induced Migration of Endometrial Stromal Cells From Ectopic Endometrium 2016
- Endometriosis Leads to an Increased Trefoil Factor 3 Concentration in the Peritoneal Cavity but Does Not Alter Systemic Levels 2016
- Endometriosis Leads to an Increased Trefoil Factor 3 Concentration in the Peritoneal Cavity but Does Not Alter Systemic Levels 2016
- Panels of cytokines and other secretory proteins as potential biomarkers of ovarian endometriosis 2015
- Diagnostic potential of peritoneal fluid biomarkers of endometriosis 2015
- Does dienogest influence the inflammatory response of endometriotic cells? A systematic review 2015
- Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125 2015
- Role of Environmental Pollutants in Endometriosis 2015
- Enhanced inflammatory activity of endometriotic lesions from the rectovaginal septum 2013
- Interplay between Misplaced Müllerian-Derived Stem Cells and Peritoneal Immune Dysregulation in the Pathogenesis of Endometriosis 2013
- A Critical Review of Endometriosis Pathology 2013
- Increased expression of pattern recognition receptors and nitric oxide synthase in patients with endometriosis 2013
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- europepmc
- last seen: 2026-10-10T06:11:15.153948+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:10:28.861444+00:00
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