Endometriosis Leads to an Increased Trefoil Factor 3 Concentration in the Peritoneal Cavity but Does Not Alter Systemic Levels

Diana Henze, Wolf‐Dietrich Doecke, Wolf-Dietrich Doecke, Daniela Hornung, Inoncent Agueusop, Oliver von Ahsen, Kathrin Machens, K. Machens, Arndt A Schmitz, Isabella Gashaw
Reproductive sciences (Thousand Oaks, Calif.) · 2016 · vol. 24(2) , pp. 258–267 · doi:10.1177/1933719116653676 · PMID:27330011 · W2469356399
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Endometriosis elevates peritoneal fluid trefoil factor 3 (TFF3) correlating with disease biomarkers, while serum TFF3 levels fluctuate with the menstrual cycle but not disease state.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The study investigated whether trefoil factor 3 (TFF3) is locally increased and associated with established endometriosis biomarkers and inflammatory markers, using peritoneal fluid and serum samples from women with or without endometriosis and an induced endometriosis mouse model. Women with endometriosis had significantly higher TFF3 concentrations in peritoneal fluid, which correlated with local CA125, CA19–9, interleukin-8, monocyte chemotactic protein-1, and matrix metalloproteinase 7, while serum TFF3 levels were influenced by menstrual cycle but were not associated with disease status; mice showed local TFF3 elevation in early endometriosis that paralleled markers of systemic inflammation (spleen weight). A major caveat is that serum results were confounded by menstrual-cycle effects, limiting disease-state interpretation for systemic TFF3. This paper is centrally about endometriosis — it demonstrates increased local peritoneal TFF3 concentration in endometriosis without changes in systemic levels.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Peritoneal Cavity Trefoil Factor-3 Adult Animals Ascitic Fluid Biomarkers Biomarkers Chemokine CCL2 Chemokine CCL2 Endometriosis Endometriosis Female Humans Interleukin-8 Interleukin-8 Matrix Metalloproteinase 7 Matrix Metalloproteinase 7 Menstrual Cycle

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