Impact of endometriosis on IVF outcomes

Adam Gafni-Kane, Danielle Vitiello, Aydın Arıcı
In: Expert Review of Obstetrics & Gynecology · 2009 · vol. 4(2) , pp. 125–132 · doi:10.1586/17474108.4.2.125 · W2046237271
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This review examines how endometriosis may cause infertility in women by affecting embryo quality, endometrial receptivity, implantation, oocyte quality, and causing pelvic adhesions.

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Abstract

Endometriosis, a disease of reproductive-age women, is defined by the identification of aberrant growth of endometrial glands or stroma in sites outside of the uterine cavity. Endometriosis is a spectrum of disease spanning from minimal disease (stage I; <5 mm of peritoneal implants) to severe disease (stage IV; ovarian endometriomas and pelvic adhesions). Often, women with endometriosis require IVF to conceive. However, to date, there is a lack of large, randomized controlled trials that assess the efficacy of IVF in the treatment of infertility in women with endometriosis. Whether endometriosis is culpable in depressing the natural fecundity of affected women remains controversial. Similarly debated are the adverse effects of endometriosis on the success of IVF. This review examines the purported means by which endometriosis may render a women either subfertile or infertile. These associations include: embryotoxicity, altered endometrial receptivity, dysfunctional implantation, poorer oocyte quality and structural limitations, such as pelvic adhesions.

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Condition tags

endometriosisinfertility

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (73)

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