Pro-endometriotic niche in endometriosis

Liang Y, Yanchun Liang, Wu J, Jinjie Wu, Wang W, Wei Wang, Hongyu Xie, Xie H, Shuzhong Yao
Reproductive BioMedicine Online · 2018 · vol. 38(4) , pp. 549–559 · doi:10.1016/j.rbmo.2018.12.025 · PMID:30772194 · W2906157755
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This paper examines the pro-endometriotic niche and its role within endometriosis.

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Abstract

Endometriosis is a complex and heterogeneous disorder of unknown aetiology. This benign disease possesses special biological behaviours that mimic those of malignant tumours. A pro-endometriotic niche established by an existing lesion is a supportive micro-environment for the progression of endometriosis. After the accumulation of cells by an existing lesion, these components display distinct characteristics that impair immune surveillance. Subsequent retrograde menstruation of endometrial stromal cells into the pro-endometriotic niche facilitates endometriotic progression from early initiation to an advanced lesion. This study aimed to highlight the innovative role of the pro-endometriotic niche in endometriosis, and to provide valuable treatment targets for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Chemokines Cytokines Endometriosis Endometrium Menstruation Disturbances Cell Adhesion Cell Adhesion Cell Proliferation Cell Proliferation Cells, Cultured Cells, Cultured Chemokines Chemokines Cytokines Cytokines Dendritic Cells Dendritic Cells Dendritic Cells Disease Progression Disease Progression

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (38)

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