Ovarian steroid hormones differentially regulate thrombospondin-1 expression in cultured endometrial stromal cells: implications for endometriosis

Xian-Jie Tan, Xianjie Tan, Tan XJ, Jing-He Lang, Jinghe Lang, Lang JH, Weiming Zheng, Zheng WM, Wei-Ming Zheng, Leng JH, Jinhua Leng, Jin-Hua Leng, Lan Zhu, Zhu L
Fertility and sterility · 2009 · vol. 93(1) , pp. 328–331 · doi:10.1016/j.fertnstert.2009.06.060 · PMID:19732880 · W2077529136
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This study investigated how ovarian steroid hormones affect thrombospondin-1 (TSP-1) expression in cultured endometrial stromal cells, finding differential regulation relevant to endometriosis.

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Abstract

Thrombospondin-1 messenger RNA and protein levels in cultured human endometrial stromal cells (ESCs) treated with 17-beta estradiol (10 nM) were reduced by 47.6% (+/-6.5% SD; P < 0.05) and 49.0% (+/-8.6%; P < 0.05) compared with untreated cells, whereas thrombospondin-1mRNA and protein levels in ESCs treated with progesterone (10 microM) were 2.1-fold (+/-0.4 SD; P < 0.05) and 2.3-fold (+/-0.6; P < 0.05) higher than those in untreated cells. These findings not only provide evidence for the estrogen dependence of endometriosis, but also partly explain the mechanisms by which progestins exert their therapeutic activities in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Estradiol Ovary Progesterone Stromal Cells Thrombospondin 1 Cells, Cultured Endometriosis Endometriosis Endometrium Endometrium Estradiol Female Humans Ovary Progesterone RNA, Messenger RNA, Messenger Stromal Cells

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