Pelvic macrophages in normal and infertile women: the role of patent tubes
Observational
OA: closed
CC0
⤵ 70 in-corpus citations
AI-generated summary
This paper examines pelvic macrophages in women with normal fertility and infertility, investigating the influence of patent fallopian tubes on macrophage populations and function.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
The volume of peritoneal fluid and its macrophage content were examined in 80 women undergoing laparoscopy. The amount of pelvic fluid was not dependent on the patency of the fallopian tubes, and no statistical difference in the fluid volume was observed between the infertile groups, including those with endometriosis, as compared to the fertile group. The number of pelvic macrophages in fertile women was extremely high during the menstrual period, and during the rest of the cycle, it remained at a basal level. The number of pelvic macrophages in women with occluded tubes was low. Four of 21 infertile patients with mild endometriosis had very high numbers of pelvic macrophages, even in the luteal phase. These results suggest that the passage of endometrial irritants through the tubes elicits a macrophage response in the peritoneal cavities of both normal women and patients with endometriosis. Although most patients with endometriosis had normal numbers of peritoneal macrophages, it is possible that these macrophages differ qualitatively from normal, and this could explain the associated infertility.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (18)
- A proposed classification of pelvic endometriosis via openalex
- Endometriosis and infertility via openalex
- New aspects of the pathophysiology of endometriosis and associated infertility via openalex
- Origin of peritoneal fluid in women: an ovarian exudation product via openalex
- Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
- Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1 alpha in endometriosis via openalex
- Peritoneal fluid volume in endometriosis via openalex
- Sperm Phagocytosis by Human Peritoneal Macrophages via openalex
- Unexplained infertility. A reappraisal via openalex
- W6714047319 via openalex
- W1509943896 via openalex
- W1969627080 via openalex
- W2021513452 via openalex
- W2080201314 via openalex
- W2104668417 via openalex
- W2409510670 via openalex
- W6687597856 via openalex
- W23961732 via openalex
Cited by (50)
- Niclosamide As a Potential Nonsteroidal Therapy for Endometriosis That Preserves Reproductive Function in an Experimental Mouse Model 2016
- Asymmetric dimethylarginine (ADMA), nitric oxide metabolite, and estradiol levels in serum and peritoneal fluid in women with endometriosis 2015
- Die Wirkung von hCG auf die Dezidualisierung ektoper endometrialer Läsionen als therapeutischer Ansatz zur Behandlung der Endometriose 2014
- Reduced hemopexin levels in peritoneal fluid of patients with endometriosis 2013
- Pelvic endometriosis with peritoneal fluid reduces pregnancy rates in women undergoing intrauterine insemination 2013
- C-reactive protein of serum and peritoneal fluid in endometriosis 2012
- Endometriosis: Disease Classification and Behavior 2011
- The 'incessant menstruation' hypothesis: a mechanistic ovarian cancer model with implications for prevention 2011
- Models of Endometriosis: Animal Models I – Rodent‐Based Chimeric Models 2011
- Semi-invasive Diagnosis of Endometriosis Doctoral Thesis 2010
- Quantity and quality of retrograde menstruation: a case control study 2009
- Differential interleukin-6 messenger ribonucleic acid expression and its distribution pattern in eutopic and ectopic endometrium 2008
- Endometriosis as a model for inflammation-hormone interactions in ovarian and breast cancers 2006
- Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis 2006
- Animal studies in endometriosis: a review 2004
- Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element 2003
- Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease? 2003
- Endometriosis and ovarian cancer: thoughts on shared pathophysiology 2003
- Immunology and endometriosis 2003
- Diagnosis and treatment of endometriosis 2003
- Macrophages, oxidation, and endometriosis 2002
- Marked elevation of macrophage migration inhibitory factor in the peritoneal fluid of women with endometriosis 2002
- Effect of menstruation and intrapelvic injection of endometrium on inflammatory parameters of peritoneal fluid in the baboon (Papio anubis and Papio cynocephalus) 2001
- Treating endometriosis as an autoimmune disease 2001
- Behandlung der Endometriose 1999
- Pathophysiology of endometriosis-associated infertility 1999
- Tracing cellular and molecular mechanisms involved in endometriosis 1998
- Fertility drugs and ovarian epithelial cancer: the endometriosis hypothesis 1997
- Correlation of basal menses CA-125 levels and 6 month pregnancy rates in women undergoing treatments for infertility without assisted reproductive methods 1997
- Increased prevalence and recurrence of retrograde menstruation in baboons with spontaneous endometriosis 1996
- Immunological aspects of endometriosis 1996
- PGE2 and PGF2 alpha release by human peritoneal macrophages in endometriosis 1996
- Effect of endometriosis on white blood cell subpopulations in peripheral blood and peritoneal fluid of baboons 1996
- Pathogenesis of Infertility in Endometriosis 1995
- An elicited intraperitoneal inflammatory response has no effect on the establishment of pregnancy in the mouse 1994
- Endometriosis: Immune Cells and Their Products 1994
- Laser laparoscopy—indications, techniques and results 1993
- Endometriosis: the host response 1993
- Inflammatory reaction in endometriotic tissue: an immunohistochemical study 1993
- The effect of growth factors on the proliferation of human endometrial stromal cells in culture 1993
- Angiogenic activity of peritoneal fluid from women with endometriosis 1993
- Menstruation as the pelvic aggressor 1993
- The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro 1992
- In vitro lymphocyte activity in women with endometriosis--an altered immune response? 1992
- The origin of estrogens, progesterone, androgens and sex hormone binding globulin in peritoneal fluid in the immediate postovulatory period in normal ovulating women 1991
- Peritoneal fluid and plasma levels of human macrophage colony-stimulating factor in relation to peritoneal fluid macrophage content 1991
- The peritoneal environment in endometriosis 1991
- Minimal/mild endometriosis and infertility. A review 1989
- Lymphocyte activity in the presence of peritoneal fluid from fertile women and infertile women with and without endometriosis 1989
- Release of tumor necrosis factor-alpha by human peritoneal macrophages in vivo and in vitro 1989
Source provenance
- europepmc
- last seen: 2026-10-18T06:15:09.303036+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-10-08T21:58:32.052686+00:00
- unpaywall
- last seen: 2026-10-18T06:28:46.490043+00:00
License: CC0
· commercial use OK