Pituitary and testicular function studies. I. Experience with a new gonadal inhibitor, 17-alpha-pregn-4-en-20-yno-(2,3-d)isoxazol-17-ol (Danazol)
Non-randomised trial
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⤵ 60 in-corpus citations
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Danazol, an ethinyl testosterone analogue, inhibited pituitary-testicular function in normal males by reducing testosterone and androstenedione plasma levels and decreasing urinary FSH excretion.
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Abstract
The effects of an ethinyl testosterone analogue, 17α-pregn-4-en-20-yno-(2,3-d) isoxazol-17-ol (Danazol), on the pituitary-testicular function of normal males are described. This compound has been shown to have an impeded androgenic effect in hypophysectomized male rats but no estrogenic or progestational activity. When administered to adult human males in doses of 200 or 600 mg daily, Danazol produced decreases in plasma levels of testosterone (T) and androstenedione (A) which were dose related. Changes in plasma steroid concentration were associated with symptoms of androgen withdrawal. Despite the marked reduction in plasma T, serum LH titers remained unchanged with the low dose but declined with the high dose schedule. Urinary FSH excretion titers decreased only during the high dose schedules of Danazol. HCG restored T to normal levels in the Danazol treated men within 4 days. Clomiphene administration produced increased serum LH and T levels in Danazol treated men as well as in untreated men. Plasma levels of dehydroepiandrosterone declined after 11 weeks of 600 mg of Danazol; base line cortisol levels and adrenal responsiveness to ACTH were not significantly different from those observed in untreated normal males. No uniform changes in sperm concentration or morphology were noted. It appears that Danazol may exert a dual effect in normal men: 1) inhibition of gonadotropin release and 2) direct inhibition of Leydig cell androgen synthesis.
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Cited by (50)
- Effects of Danazol on the epididymal function in male langurs (Presbytis entellus entellus Dufresne) 2009
- Reversible inhibition of spermatogenesis by danazol with combination of testosterone enanthate in rabbit 2009
- Effects of danazol on DNA synthesis in rat prostate 1993
- Adrenal steroids in serum during danazol therapy, taking into account cross-reactions between danazol metabolites and serum androgens 1993
- Suppression of the development of uterine adenomyosis by danazol treatment in mice 1992
- Danazol: in vitro effects on human hemopoiesis and in vivo activity in hypoplastic and myelodysplastic disorders 1991
- Testis functions and sexual potentia in langur monkey treated with a combination steroidal contraceptive formulation 1986
- Danazol treatment of advanced prostate cancer: clinical and hormonal effects 1986
- Dosage-related effects of danazol on sex hormone binding globulin and free and total androgen levels 1986
- Treatment with danazol of ureteral obstruction caused by endometriosis 1985
- Changes in the biochemical composition of semen following danazol plus testosterone enanthate administration to the langur monkey 1985
- Gynecologic Problems of Adolescence 1985
- Endocrine effects of danazol in the treatment of endometriosis 1984
- Structural and functional changes in epididymis following danazol plus testosterone enanthate administration in rabbit 1983
- Peripheral androgen levels in danazol-treated premenopausal women 1983
- Free testosterone levels during danazol therapy 1983
- Dynamic tests of hypothalamic and pituitary function in women treated with danazol 1982
- Danazol 1982
- Effect of danazol on gonadal steroidogenesis in patients with a complete form of testicular feminization 1982
- Danazol and gestagen displacement of testosterone and influence on sex-hormone-binding globulin capacity 1982
- Actions of danazol in vivo on cytochrome P-450 and steroidogenic enzymes in rat testis and liver microsomal preparations 1981
- Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma 1981
- A histochemical study of the effect of danazol and oestradiol-17 beta on steroidogenic activity in testis and epididymis of the gerbil, Tatera indica 1981
- Transient adrenogenital syndrome due to exposure to danazol in utero 1981
- Structural and functional regression of polycystic ovaries by danazol 1981
- The use of danazol for ureteral obstruction caused by endometriosis 1981
- Cholesterol, high density lipoprotein and danazol 1981
- In vitro effect of danazol on luteinizing hormone-releasing hormone-stimulated luteinizing hormone release in rat anterior pituitary cell cultures in vitro 1981
- Pharmacology and pharmacokinetics of danazol 1980
- Review: The mechanism of action of danazol, a novel steroid derivative 1980
- Competitive inhibition by danazol of oestradiol binding to rabbit and ovine uterine oestradiol receptor 1980
- Evidence that danazol inhibits gonadotropin-induced ovarian steroidogenesis at a point distal to gonadotropin-receptor interaction and adenosine 3',5' cyclic monophosphate formation 1980
- Danazol inhibits human adrenal 21-and 11 beta-hydroxylation in vitro 1980
- Effect of danazol on serum gonadotrophins and steroid hormone concentrations in women with menorrhagia 1980
- Inhibition of adrenal steroidogenesis by danazol in vivo 1980
- The "treatment" of unexplained infertility with danazol 1979
- Analysis of progesterone in unextracted serum: a method using danazol [17 alpha-pregn-4-en-20-yno(2, 3-d) isoxazol-17-ol] a blocker of steroid binding to proteins 1979
- Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity 1979
- Danazol--a steroid with a unique combination of actions 1979
- Effect of danazol on estradiol-17beta and progesterone secretion by porcine ovarian cells in vitro 1979
- A radioimmumoassay for danazol (17α-Pregna-2,4-Dien-20-Yno[2,3-d]Isoxazol-17-OL) 1978
- Effects of Danazol on pituitary gonadotrophins in post-menopausal women 1978
- Pituitary gonadotropin responsiveness with danazol 1978
- Danazol effects on gonadotropin basal levels and pituitary responsiveness to LH-RH in immature male rats 1978
- Effects of danazol on gonadotropin secretion after ovariectomy in rats 1978
- Selective inhibition by danazol of follicle stimulating hormone during the luteal phase 1977
- Danazol therapy in hormone-sensitive mammary carcinoma 1977
- Danazol: an antigonadotrophic agent in the treatment of recurrent pelvic and intestinal endometriosis 1977
- Danazol Inhibits Steroidogenesis 1977
- The effect of danazol on anterior pituitary function 1977
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