A histochemical study of the effect of danazol and oestradiol -17β on steroidogenic activity in testis and epididymis of the gerbil, Tatera indica

M. Chandrakala; Hironmoy Sarkar

doi:10.1530/jrf.0.0610217

A histochemical study of the effect of danazol and oestradiol -17β on steroidogenic activity in testis and epididymis of the gerbil, Tatera indica

M. Chandrakala, Hironmoy Sarkar

In: Reproduction · 1981 · vol. 61(1) , pp. 217–220 · doi:10.1530/jrf.0.0610217 · PMID:6935436 · W2160602690

article OA: closed CC0 ⤵ 2 in-corpus citations

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Danazol and oestradiol-17β administration reduced gerbil testis and accessory organ weights, decreased steroidogenic enzyme activities, and caused lipid accumulation, indicating inhibition of testicular function.

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Abstract

Danazol (4 mg/day/animal) and oestradiol-17 beta (100 microgram/day/animal) were administered subcutaneously for 22 and 15 days respectively. The testis and epididymis were histochemically analysed for steroid dehydrogenases, NADH-diaphorase, glucose 6-phosphate dehydrogenase activity and lipids. Both steroids significantly reduced the weights of the testis and other accessory reproductive organs. The activities of delta 5-3 beta- and 17 beta-HSD were markedly reduced in the seminiferous epithelium and interstitial cells of the testis. Sudanophilic lipids accumulated in the seminiferous tubules and the interstitium. Oestradiol generally had a greater effect than did danazol, but both probably affect the testicular function by inhibiting steroidogenesis.

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References (14)

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Effects of Danazol on the Pituitary-Gonadal Axis in Male Gerbils and Mice via openalex
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doi:10.1530/acta.0.0770636 via openalex
doi:10.1210/endo-85-1-96 via openalex

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[1] Contraceptive properties of Danazol. via openalex

[2] Danazol Inhibits Steroidogenesis via openalex

[3] Effects of Danazol on the Pituitary-Gonadal Axis in Male Gerbils and Mice via openalex

[4] Pituitary and Testicular Function Studies. I. Experience with a New Gonadal Inhibitor, 17α-Pregn-4-en-20-yno-(2,3-d) isoxazol-17-ol (Danazol)<sup>1</sup> via openalex

[5] The Effect of Danazol on Anterior Pituitary Function via openalex

[6] doi:10.1016/0039-128x(76)90068-4 via openalex

[7] doi:10.1007/bf00577840 via openalex

[8] doi:10.1016/0016-6480(66)90076-1 via openalex

[9] doi:10.1098/rspb.1974.0041 via openalex

[10] doi:10.1001/jama.1953.02940280072039 via openalex

[11] doi:10.1016/0303-7207(75)90051-9 via openalex

[12] doi:10.1095/biolreprod17.5.645 via openalex

[13] doi:10.1530/acta.0.0770636 via openalex

[14] doi:10.1210/endo-85-1-96 via openalex