A histochemical study of the effect of danazol and oestradiol-17 beta on steroidogenic activity in testis and epididymis of the gerbil, Tatera indica

M. Chandrakala, M V Chandrakala, H B Sarkar, Hironmoy Sarkar
Journal of reproduction and fertility · 1981 · vol. 61(1) , pp. 217–220 · doi:10.1530/jrf.0.0610217 · PMID:6935436 · W2160602690
Lab / animal OA: closed CC0 ⤵ 2 in-corpus citations
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Danazol and oestradiol-17β administration reduced gerbil testis and accessory organ weights, decreased steroidogenic enzyme activities, and caused lipid accumulation, indicating inhibition of testicular function.

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Abstract

Danazol (4 mg/day/animal) and oestradiol-17 beta (100 microgram/day/animal) were administered subcutaneously for 22 and 15 days respectively. The testis and epididymis were histochemically analysed for steroid dehydrogenases, NADH-diaphorase, glucose 6-phosphate dehydrogenase activity and lipids. Both steroids significantly reduced the weights of the testis and other accessory reproductive organs. The activities of delta 5-3 beta- and 17 beta-HSD were markedly reduced in the seminiferous epithelium and interstitial cells of the testis. Sudanophilic lipids accumulated in the seminiferous tubules and the interstitium. Oestradiol generally had a greater effect than did danazol, but both probably affect the testicular function by inhibiting steroidogenesis.

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MeSH descriptors

Danazol Epididymis Estradiol Pregnadienes Testis Animals Danazol Epididymis Epididymis Estradiol Gerbillinae Histocytochemistry Hydroxysteroid Dehydrogenases Hydroxysteroid Dehydrogenases Male Organ Size Organ Size Pregnadienes Testis Testis

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