Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis

Chun Yang, Yang C, Geng Y, Yuhong Geng, Li Y, Yanhui Li, Chunyan Chen, Chen C, Gao Y, Ying Gao
Reproductive BioMedicine Online · 2015 · vol. 31(1) , pp. 9–19 · doi:10.1016/j.rbmo.2015.03.005 · PMID:25982092 · W2165906761
Systematic review / meta-analysis OA: closed CC0 ⤵ 90 in-corpus citations
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This systematic review and meta-analysis investigated the impact of ovarian endometriomas on ovarian responsiveness and IVF outcomes.

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Abstract

In this systematic review and meta-analysis, the effect of ovarian endometrioma on ovarian responsiveness to stimulation and on assisted reproduction outcomes was evaluated. Nine published studies (1039 cases) were included. The number of oocytes retrieved (mean difference [MD] -1.50; 95% CI, -2.84 to -0.15, P = 0.03), metaphase II (MII) oocytes retrieved (MD -3.61; 95% CI -4.44 to -2.78, P < 0.00001) and total embryos formed (MD -0.66; 95% CI -1.13 to -0.18, P = 0.007) were significantly lower in women with ovarian endometrioma than the control group. Gonadotrophin dose, duration of stimulation, number of good-quality embryos, implantation rate, clinical pregnancy rate and live birth rate were similar. Comparisons between ovaries with endometriomas and healthy ovaries of the same individuals were also made. Number of oocytes retrieved, MII oocytes retrieved and total embryos formed were not statistically significantly different between the affected ovaries and contralateral normal ovaries. Observational studies showed that ovarian endometrioma was associated with fewer oocytes retrieved, fewer MII oocytes retrieved and fewer total formed embryos. Clinical pregnancy rate and live birth rates were not affected. Intra-patient comparisons in women with unilateral endometrioma suggested the number of oocytes retrieved, MII oocytes retrieved and total embryos formed were similar.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Fertilization in Vitro Fertilization in Vitro Ovarian Diseases Ovary Ovulation Induction Ovulation Induction Birth Rate Birth Rate Embryo Implantation Embryo Implantation Endometriosis Endometriosis Female Female Humans Humans Ovarian Diseases Ovarian Diseases Ovary

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (48)

Cited by (50)

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