Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis

Bourlev V, Vladimir Bourlev, Anders Larsson, Larsson A, Matts Olovsson, Olovsson M
American journal of obstetrics and gynecology · 2006 · vol. 194(3) , pp. 755–759 · doi:10.1016/j.ajog.2005.08.064 · PMID:16522409 · W2105788721
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This study investigated fibroblast growth factor-2 (FGF-2) levels in serum from women with endometriosis and found they were elevated compared to controls.

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Abstract

OBJECTIVE: The purpose of this study was to determine whether serum and peritoneal fluid levels of fibroblast growth factor-2 (FGF-2) differ between women with and without endometriosis and to examine the relationship between proliferative activity in the endometriotic lesions and the levels of FGF-2 in serum and peritoneal fluid. STUDY DESIGN: Biopsy specimens of peritoneal endometriotic lesions (n = 25) were analyzed immunohistochemically regarding proliferative activity in stroma, glands, and blood vessels. The FGF-2 concentration was measured in peritoneal fluid and serum from 25 women with endometriosis and 14 healthy controls. RESULTS: Patients with endometriosis had higher serum concentrations of FGF-2 during both the proliferative and secretory menstrual phases than healthy women. Peritoneal fluid levels of FGF-2 differed significantly between women with high and low proliferative activity in their endometriotic lesions. CONCLUSION: Women with endometriosis have a higher serum level of FGF-2 than healthy controls.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fibroblast Growth Factor 2 Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Biomarkers Biomarkers Biomarkers Cell Proliferation Cell Proliferation Endometriosis Endometriosis Endometriosis Female Female Fibroblast Growth Factor 2 Fibroblast Growth Factor 2 Fibroblast Growth Factor 2

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (32)

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