Uterine chemokines in reproductive physiology and pathology

Kayisli UA, Umit A. Kayisli, Mahutte NG, Neal G Mahutte, Neal Mahutte, Aydin Arici, Aydın Arıcı, Arici A
American journal of reproductive immunology (New York, N.Y. : 1989) · 2002 · vol. 47(4) , pp. 213–221 · doi:10.1034/j.1600-0897.2002.01075.x · PMID:12069388 · W2084426473
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This review discusses the role of uterine chemokines like IL-8, MCP-1, and RANTES in regulating endometrial angiogenesis, apoptosis, proliferation, and differentiation, impacting both normal reproduction and conditions like endometriosis.

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Abstract

PROBLEM: Chemokines are increasingly recognized as important regulators of uterine function. METHODS OF STUDY: The following is a review of uterine chemokines, especially monocyte chemotactic protein (MCP)-1, interleukin (IL)-8, and regulated-upon-activation normal-T-cell-expressed and -secreted (RANTES) protein, in reproductive physiology and pathology. RESULTS: It is increasingly clear that IL-8, MCP-1, RANTES and their receptors are produced by endometrial, myometrial, and trophoblast cell types in a timed and co-ordinated manner. In addition to the regulation of leukocyte migration and function, uterine chemokines also display specific roles in endometrial angiogenesis, apoptosis, proliferation, and differentiation. IL-8, MCP-1 and RANTES are regulated by local growth factors and cytokines such as tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and IL-1. IL-8 takes part in cervical ripening and parturition. IL-8, MCP-1 and RANTES are also found at high levels in the peritoneal fluid of women with endometriosis. CONCLUSION: Co-ordination of chemokine-chemokine receptor interactions plays an important role in the menstrual cycle and successful pregnancy. Moreover, unbalanced chemokine expression contributes to pathologic conditions typified by uncontrolled cellular proliferation, migration and invasion.

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Condition tags

endometriosis

MeSH descriptors

Chemokines Reproduction Uterus Cervical Ripening Cervical Ripening Cervical Ripening Chemokine CCL2 Chemokine CCL2 Chemokine CCL2 Chemokine CCL5 Chemokine CCL5 Chemokine CCL5 Chemokines Chemokines Chemokines Endometriosis Endometriosis Endometriosis Endometriosis Endometrium

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (77)

Cited by (43)

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License: CC0 · commercial use OK