Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1 alpha in endometriosis
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⤵ 107 in-corpus citations
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This study measured peritoneal fluid levels of thromboxane B2 and 6-keto-prostaglandin F1α in women with and without endometriosis to investigate their roles in the condition.
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Abstract
An anatomic basis for the infertility associated with endometriosis is often lacking. The present study measured peritoneal fluid levels of two of the stable products of prostaglandin endoperoxides (thromboxane B2 and 6-keto-prostaglandin F1 alpha) in patients with and without endometriosis. Both compounds were significantly elevated in the endometriosis group (n = 15, p less than 0.05). This suggests an increase in the peritoneal fluid levels of thromboxane A2 and prostacyclin, both of which could act on tubal smooth muscle and interfere with tubal function. Such altered tubal function might explain the phenomenon of endometriosis-induced infertility when there is no direct damage to the reproductive organs.
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Cited by (50)
- Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16- NK-cell differentiation 2022
- Identification and analysis of novel endometriosis biomarkers via integrative bioinformatics 2022
- Comparison of endometrial prostanoid profiles in three infertile subgroups: the missing part of receptivity? 2020
- Uterine wall thickness at the second trimester can predict subsequent preterm delivery in pregnancies with adenomyosis 2019
- How to Understand the Complexity of Endometriosis-Related Pain 2017
- Management of endometriosis‐related pelvic pain 2017
- The role of the sympathetic nervous system and semaphorins in the pathogenesis of endometriosis 2016
- [Endometriosis : An often unrecognized pain disorder] 2016
- Endometriosis-Derived Thromboxane A2 Induces Neurite Outgrowth 2016
- Endometriose: Pathogenese, Symptome und Diagnostik 2015
- The peritoneum--an important factor for pathogenesis and pain generation in endometriosis 2014
- Successful pregnancy in a case of bladder and ovary endometriosis following cystoscopy-assisted laparoscopic resection 2014
- Induction of the neurokinin 1 receptor by TNFα in endometriotic tissue provides the potential for neurogenic control over endometriotic lesion growth 2013
- Neuroimmunomodulatory alterations in non-lesional peritoneum close to peritoneal endometriosis 2012
- Effect of antiangiogenic treatment on peritoneal endometriosis-associated nerve fibers 2012
- Cellular and molecular basis for endometriosis-associated infertility 2012
- Relationship between Toll-like receptor-4 and mPGES-1 gene expression in local lesions of endometriosis patients 2012
- Pathophysiology of Infertility in Endometriosis 2011
- Influence of nerve growth factor in endometriosis-associated symptoms 2011
- Endometriosis 2011
- The influence of peritoneal endometriotic lesions on the generation of endometriosis-related pain and pain reduction after surgical excision 2009
- Pyruvate reduces in vitro the embryotoxic effect of peritoneal fluid from infertile women with endometriosis 2008
- A pilot study to evaluate the clinical relevance of endometriosis-associated nerve fibers in peritoneal endometriotic lesions 2008
- Endometriose und Inflammation 2007
- Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients 2007
- Adenomyosis and risk of preterm delivery 2006
- Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilization 2006
- Increased cyclooxygenase-2 expression is associated with better clinical outcome in patients submitted to complete ablation for severe endometriosis 2005
- Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters 2004
- Peritoneal Endometriosis 2000
- Effect of peritoneal fluid from women with endometriosis on implantation in the mouse model 2000
- Pathophysiology of endometriosis-associated infertility 1999
- Treatment of infertility associated with endometriosis 1998
- Endometriosis and Pelvic Pain 1998
- Prolactin secretion in endometriotic patients 1997
- Increased secretion of hepatocyte growth factor by eutopic endometrial stromal cells in women with endometriosis 1997
- Endometriosis-associated infertility 1997
- Pathophysiology. The biologic principles of disease 1997
- The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro 1996
- Review of Peritoneal Factors that Affect Fertility in Patients With Mild Endometriosis 1996
- In vitro sperm phagocytosis by human peritoneal macrophages in endometriosis-associated infertility 1996
- PGE2 and PGF2 alpha release by human peritoneal macrophages in endometriosis 1996
- Pathogenesis of Infertility in Endometriosis 1995
- Pathogenesis of Pelvic Pain in Endometriosis 1995
- Endometrial leukocyte subpopulations in women with endometriosis 1995
- Treatment of Infertility Associated With Endometriosis 1995
- Elevation of the phospholipase A2 activity in peritoneal fluid cells from women with endometriosis 1994
- Aberrant integrin expression in the endometrium of women with endometriosis 1994
- The use of arachidonic acid in some gynaecological disorders 1994
- Biochemische Aspekte der Endometriose 1993
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