Peritoneal fluid interleukin-1 beta and tumor necrosis factor in patients with benign gynecologic disease

Mori H, H Mori, Hidehiro Mori, M Sawairi, Miho Sawairi, Sawairi M, Nakagawa M, M Nakagawa, Naoki Itoh, N Itoh, Itoh N, KEISUKE WADA, Wada K, K Wada, Tamaya T, Teruhiko Tamaya, T Tamaya
American journal of reproductive immunology (New York, N.Y. : 1989) · 1991 · vol. 26(2) , pp. 62–67 · doi:10.1111/j.1600-0897.1991.tb00972.x · PMID:1768319 · W2011263448
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Peritoneal fluid IL-1β was elevated in acute pelvic inflammatory disease and early endometriosis, while TNF was elevated in pelvic inflammatory disease and all stages of endometriosis.

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Abstract

The levels of interleukin 1 beta (IL-1 beta) and tumor necrosis factor (TNF) in peritoneal fluid (PF-IL-1 beta and PF-TNF) and production of IL-1 beta and TNF by peritoneal macrophages were determined in patients with benign gynecologic disease. The level of PF-IL-1 beta was elevated in the acute pelvic inflammatory disease (PID) and stages I and II endometriosis (E I/II) groups compared with the normal pelvis group, but not in the myoma of the uterus, ovarian cyst, and postinflammatory pelvic adhesion groups. The level of PF-TNF was elevated in the PID, EI/II and stages III and IV endometriosis (EIII/IV) groups. There was no correlation between the levels of PF-IL-1 beta and PF-TNF. Neither the level of PF-IL-1 beta nor that of PF-TNF was correlated with the concentration of peritoneal macrophages. Peritoneal macrophages produced IL-1 beta and TNF in vitro in the absence of stimulants. The levels of PF-IL-1 beta and PF-TNF are presumably linked to the activation of peritoneal macrophages.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Genital Diseases, Female Interleukin-1 Macrophages Tumor Necrosis Factor-alpha Adult Adult Ascitic Fluid Ascitic Fluid Cell Count Cell Count Chi-Square Distribution Chi-Square Distribution Female Female Genital Diseases, Female Genital Diseases, Female Humans Humans Interleukin-1

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References (21)

Cited by (50)

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