Experimental endometriosis: the nude mouse as a xenographic host

Kaylon L. Bruner‐Tran, Kaylon L Bruner-Tran, Webster-Clair D, Deborah Webster-Clair, DEBORAH WEBSTER‐CLAIR, Kevin G. Osteen, Osteen KG
Annals of the New York Academy of Sciences · 2002 · vol. 955(1) , pp. 328–339 · doi:10.1111/j.1749-6632.2002.tb02793.x · PMID:11949959 · W169066046
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This study developed an experimental endometriosis model in nude mice using human tissues to investigate steroid-associated regulation of matrix metalloproteinases, finding that progesterone and related cytokines prevent disease establishment.

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Abstract

Endometriosis is a complex disease that can develop as a consequence of retrograde menstruation, occurring in association with the cyclic loss of endometrial tissue in primates and humans. In addition, progression of disease parallels a woman's exposure to ovarian steroids, rarely occurring prior to menarche and generally resolving following menopause. Because of the cost of developing primate models to study endometriosis, numerous small animal models have been established to approach various elements related to the pathophysiology of this disease. Our laboratory has developed an experimental endometriosis model using nude mice as a xenographic host for human tissues. Our goal is to approach the basic cellular mechanisms of estrogen and progesterone action that link these hormones to the development or prevention of endometriosis. In our initial studies, we have sought to understand steroid-associated regulation of matrix metalloproteinases (MMPs) with regard to the development of experimental endometriosis. Using both short-term organ cultures and nude mice as xenographic hosts of human tissue, we have demonstrated a critical role of progesterone and progesterone-associated cytokines in preventing the initial establishment of experimental disease. Women with endometriosis appear to lack normal endometrial responsiveness to progesterone, resulting in altered expression of several MMPs and an enhanced ability of these tissues to establish ectopic lesions in nude mice. Developing a better understanding of the impairments in the normal endometrial physiology of women with endometriosis should aid in the development of better treatment or diagnostic strategies.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Disease Models, Animal Endometriosis Animals Animals Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Mice Mice Mice, Nude Mice, Nude

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (50)

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