Faculty Opinions recommendation of Autonomic nervous system and inflammation interaction in endometriosis-associated pain.

Philippa T. K. Saunders
In: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021 · doi:10.3410/f.737511517.793584333 · W4214678903
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This review compares inflammation and autonomic nervous system changes in endometriosis, inflammatory bowel disease, and rheumatoid arthritis to explore neural mechanisms in endometriosis-associated pain.

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Abstract

Endometriosis is a chronic inflammatory disease. Pain is the most common symptom in endometriosis. Endometriosis-associated pain is caused by inflammation, and is related to aberrant innervation. Although the specific mechanism between endometriosis-associated pain and the interaction of aberrant innervation and inflammation remains unclear, many studies have confirmed certain correlations between them. In addition, we found that some chronic inflammatory autoimmune diseases (AIDs) such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) share similar characteristics: the changes in dysregulation of inflammatory factors as well as the function and innervation of the autonomic nervous system (ANS). The mechanisms underlying the interaction between the ANS and inflammation have provided new advances among these disorders. Therefore, the purpose of this review is to compare the changes in inflammation and ANS in endometriosis, IBD, and RA; and to explore the role and possible mechanism of sympathetic and parasympathetic nerves in endometriosis-associated inflammation by referring to IBD and RA studies to provide some reference for further endometriosis research and treatment. PMID: 32145751 Funding information This work was supported by: National Natural Science Foundation of China, Grant ID: Grant No. 81701416 Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation, Grant ID: pdjh2019a0004 Student Innovation Training Program of Sun Yat-Sen University, Grant ID: Grant No. 201901097 Natural Science Foundation of Guangdong Province (CN), Grant ID: Grant No. 2016A030310151

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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