The effect of hormones on endometriosis development

Parente Barbosa C, Caio Parente Barbosa, C Parente Barbosa, Bentes De Souza AM, Ângela Mara Bentes de Souza, A M Bentes De Souza, B Bianco, Bianca Bianco, Bianco B, Denise Maria Christofolini, Christofolini DM, D M Christofolini
Minerva ginecologica · 2011 · vol. 63(4) , pp. 375–86 · PMID:21747346 · W69077065
Review OA: closed CC0 ⤵ 35 in-corpus citations
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This review examines the interaction between endometriosis, sex hormones (estrogen and progesterone), and genetic variants, considering the potential influence of endocrine-disrupting environmental chemicals.

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Abstract

Endometriosis is a common gynecological condition in which tissue that is histologically similar to the endometrium with glands and/or stroma grows outside the uterine cavity and can lead to pelvic pain, dysmenorrhea and infertility. Many aspects of female reproductive function are strongly influenced by genetic factors and numerous studies have attempted to identify susceptibility genes for disorders affecting female fertility such as endometriosis. The importance of steroid hormones on endometriosis is unquestionable. The disease is most prevalent in women of reproductive age and regresses after menopause and its occurrence before menarche has not been reported. Sex steroids, estrogen and progesterone, are mainly produced in the ovaries and they regulate the growth of endometrial tissue, basically by stimulating and inhibiting cell proliferation, respectively. In addition, estrogen plays an important role in the regulation of cyclic gonadotropin release and in folliculogenesis. Numerous studies have been conducted to demonstrate the interaction of hormone and their receptors with endometriosis with conflict results. Besides, environmental chemicals, known as endocrine disruptors, have the capacity to mimic, block or modulate the endocrine system through the interaction with steroidal receptors. Recently evidences have proposed a putative role for ubiquitous environmental contaminants in the occurrence of endometriosis. Here, we reviewed significant articles regarding the interaction among endometriosis, hormones and genetic polymorphic variants.

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Condition tags

endometriosisdysmenorrheainfertility

MeSH descriptors

Endometriosis Hormones Endocrine Disruptors Endocrine Disruptors Endocrine Disruptors Endometriosis Endometriosis Estrogens Estrogens Estrogens Female Female Hormones Hormones Humans Humans Luteinizing Hormone Luteinizing Hormone Luteinizing Hormone Progesterone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (36)

Cited by (34)

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License: CC0 · commercial use OK