New theories in endometriosis: new knowlage may be producing novel therapies

Laila Ezzat
In: The Egyptian Journal of Fertility of Sterility · 2016 · vol. 20(2) , pp. 29–35 · doi:10.21608/egyfs.2016.19532 · W2900781339
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines current theories on endometriosis pathogenesis involving stem cells, immune dysfunction, genetics, and the peritoneal environment to identify novel therapeutic targets.

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Abstract

Endometriosis is a common, chronic inflammatory disease defined by the presence of extrauterine endometrial tissue. The aetiology of endometriosis is complex and multifactorial, where several not fully confirmed theories describe its pathogenesis.The current literature suggests that stem cells, dysfunctional immune response, genetic predisposition, and aberrant peritoneal environment may all be involved in the establishment and propagation of endometriotic lesions. An orchestrated scientific and clinical effort is needed to consider all factors involved in the pathogenesis of this multifaceted disease and to propose novel therapeutic targets to reach effective treatments for this distressing condition.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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