A prospective study of endometriosis and risk of benign breast disease

Leslie V. Farland, Rulla M Tamimi, A Heather Eliassen, Donna Spiegelman, Laura C Collins, Stuart J Schnitt, Stacey A Missmer
Breast cancer research and treatment · 2016 · vol. 159(3) , pp. 545–552 · doi:10.1007/s10549-016-3957-y · PMID:27604359 · PMC5310266 · W2512136454
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriosis was associated with a modest increased risk of biopsy-confirmed benign breast disease, particularly among women with a history of infertility.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This prospective cohort study examined whether laparoscopically confirmed endometriosis is associated with biopsy-confirmed benign breast disease (BBD) among 76,393 women in the Nurses’ Health Study II followed from 1991–2003, using Cox proportional hazards models adjusted for potential confounders. Across follow-up, 2011 BBD biopsies were centrally reviewed and categorized as nonproliferative (n=675) or proliferative (n=1336), and analyses assessed effect modification by infertility history and screening mammography use. Endometriosis was associated with a modestly increased risk of overall BBD (HR 1.20, 95% CI 1.00–1.43), with similarly modest associations for both nonproliferative and proliferative lesions, and the association for proliferative BBD appeared strongest among women with prior infertility. The authors note that the finding is novel and requires replication. This paper is centrally about endometriosis — it tests whether endometriosis predicts future benign breast disease, stratified by lesion proliferation.

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Condition tags

endometriosis

MeSH descriptors

Breast Diseases Breast Diseases Endometriosis Endometriosis Adult Biopsy Breast Diseases Endometriosis Female Humans Laparoscopy Nurses Prospective Studies Risk Factors Surveys and Questionnaires

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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