Risk of Endometriosis and Subsequent Ovary and Breast Cancers in Nurses: A Population-Based Cohort Study in Taiwan

Hsing-Chi Hsu, Hsing‐Chi Hsu, Kai-Yu Tseng, Hsiang-Chi Wang, Fung-Chan Sung, Wei‐Fen Ma
International journal of environmental research and public health · 2019 · vol. 16(18) , pp. 3469 · doi:10.3390/ijerph16183469 · PMID:31540449 · W2973791913
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found nurses have a higher risk of developing endometriosis, but the association between endometriosis and subsequent ovarian or breast cancer risk in nurses is weak.

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Abstract

BACKGROUND: Endometriosis has been associated with the subsequent development of ovarian and breast cancers. This study evaluated whether nurses were at increased risks of developing endometriosis and subsequent ovarian and breast cancers. METHODS: From Taiwan National Health Insurance Research Database during 2000 to 2011, we established 3 study cohorts, consisting of 23,801 nurses, 11,973 other hospital employees, and 143,096 general women free of endometriosis and cancer. Women in all cohorts were followed to the end of 2011 to measure the occurrences of endometriosis and subsequent ovarian and breast cancers. The incident endometriosis cases and related hazard ratio (HR) and 95% confidence interval (CI) were calculated. The incident cases of ovarian cancer and breast cancer and related odds ratio were calculated. RESULTS: = 4193), with adjusted hazard ratios of 1.28 (95% CI = 1.20-1.38) and 1.13 (95% CI = 1.02-1.25), respectively, comparing to controls. Among those who developed endometriosis, nurses had higher subsequent ovarian cancer and lower breast cancer, but not significant. CONCLUSIONS: Nurses are at a higher risk of developing endometriosis. However, the link between endometriosis and subsequent cancers is weak.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Breast Neoplasms Endometriosis Nurses Ovarian Neoplasms Adult Breast Neoplasms Breast Neoplasms Case-Control Studies Cohort Studies Endometriosis Endometriosis Female Humans Incidence Middle Aged Nurses Ovarian Neoplasms Ovarian Neoplasms Proportional Hazards Models Risk Factors

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