Monocyte-mediated enhancement of endometrial cell proliferation in women with endometriosis

Donald P. Braun, Braun DP, D P Braun, A Muriana, Muriana A, Adalberto Muriana, H Gebel, Gebel H, Howard M. Gebel, Rotman C, C Rotman, Carlos Rotman, N Rana, Nasir Rana, Rana N, W P Dmowski, Dmowski WP, W. Paul Dmowski
Fertility and sterility · 1994 · vol. 61(1) , pp. 78–84 · doi:10.1016/s0015-0282(16)56456-5 · PMID:8293848 · W2401346801
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Monocytes were found to increase the proliferation of endometrial cells in women diagnosed with endometriosis.

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Abstract

OBJECTIVE: To investigate the capacity of monocytes from women with endometriosis to influence endometrial cell proliferation. DESIGN: Uterine endometrial cells were cultured in the presence and absence of autologous blood monocytes for 72 hours before assessment of endometrial cell proliferation by thymidine incorporation. SETTING: Patients were tested at initial presentation for evaluation of infertility and/or endometriosis. PATIENTS, PARTICIPANTS: Fertile controls, n = 17; infertile controls, n = 9; untreated endometriosis, n = 29. INTERVENTIONS: None. RESULTS: Endometrial cell proliferation was enhanced significantly by blood monocytes in patients with endometriosis but was suppressed significantly by blood monocytes in fertile controls. Endometrial cell proliferation was not affected significantly by blood monocytes in infertile controls analyzed as a group, but a subset of infertile patients also showed enhancement of endometrial cell proliferation by blood monocytes. CONCLUSIONS: Blood monocytes from patients with endometriosis and a subset of patients with unexplained infertility enhance autologous endometrial cell proliferation, whereas blood monocytes from fertile patients suppress endometrial cell proliferation. The capacity of monocytes to enhance endometrial cell proliferation appears to require both monocyte-derived factors that stimulate endometrial cell proliferation and endometrial cells capable of responding to those stimulatory factors. If either of these factors is absent, monocytes either suppress or have no effect on endometrial cell proliferation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Monocytes Uterine Diseases Adult Adult Cell Division Cell Division Cell Division Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Infertility Infertility

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

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