Analytical Hypotheses on Possible Etiology and Types of Endometriosis

Bamgboye M Afolabi
In: Journal of Prevention and Infection Control · 2015 · vol. 1(1) · doi:10.21767/2471-9668.10006 · W2227818637
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper proposes two types of endometriosis: "endometrial endometriosis" arising from within the endometrium and "endometroid endometriosis" arising from outside, potentially linked to embryonic origin or viral infection.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

The paper reviews prevailing hypotheses for endometriosis etiology, including retrograde menstruation, hematological/lymphatic spread, immunologic dysfunction, and genetic predisposition, and notes the estimated global prevalence in women of reproductive age. It then proposes an alternative framework with two hypothesized types of endometriosis: one with an embryonic origin arising within the endometrium (“endometrial endometriosis”) and another driven by viral assaults on the endometrium, arising outside it (“endometroid endometriosis”). The main limitation is that the discussion is theoretical and based on hypothesis-building rather than presented empirical data or direct testing. This paper is centrally about endometriosis — it proposes two etiology-based categories (“endometrial” vs “endometroid” endometriosis) grounded in embryonic origin and viral assaults.

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Abstract

Endometriosis is a debilitating disease, of yet unknown etiology, globally affecting about 70 million women in child-bearing age. Previous hypotheses regarding the pathogenesis of endometriosis include retrograde menstruation grounded on peristaltic discharge of menstrual debris into the pelvic peritoneum to form endometrial tissue; the hematological and lymphatic spread theory which proposes seepage of menstrual wreckages into venous and/or lymphatic outflow leading to metastasis; the immunologic concept which assumes weakened or unresponsive immune system and presence of endometrial antibodies and the genetic hypothesis which is based on endometriosis being coded for in the genes of some females. This study takes into consideration imaginable embryonic origin of one type of endometriosis on one hand and on the other hand, viral assaults on the endometrium causing the other type of endometriosis. Therefore, this paper proposes two types of endometriosis, one arising from within the endometrium, which is labelled "endometrial endometriosis" and the other arising from outside the endometrium, hereby referred to as "endometroid endometriosis." These two types of endometriosis may have different presentation and probably require different management.
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Bamgboye M. Afolabi DOI10.21767/2471-9668.10006 Endometriosis is a debilitating disease, of yet unknown etiology, globally affecting about 70 million women in child-bearing age. Previous hypotheses regarding the pathogenesis of endometriosis include retrograde menstruation grounded on peristaltic discharge of menstrual debris into the pelvic peritoneum to form endometrial tissue; the hematological and lymphatic spread theory which proposes seepage of menstrual wreckages into venous and/or lymphatic outflow leading to metastasis; the immunologic concept which assumes weakened or unresponsive immune system and presence of endometrial antibodies and the genetic hypothesis which is based on endometriosis being coded for in the genes of some females. This study takes into consideration imaginable embryonic origin of one type of endometriosis on one hand and on the other hand, viral assaults on the endometrium causing the other type of endometriosis. Therefore, this paper proposes two types of endometriosis, one arising from within the endometrium, which is labelled “endometrial endometriosis” and the other arising from outside the endometrium, hereby referred to as “endometroid endometriosis.” These two types of endometriosis may have different presentation and probably require different management. Select your language of interest to view the total content in your interested language - Aquaculture & Veterinary Science - Chemistry & Chemical Sciences - Clinical Sciences - Engineering - General Science - Genetics & Molecular Biology - Health Care & Nursing - Immunology & Microbiology - Materials Science - Mathematics & Physics - Medical Sciences - Neurology & Psychiatry - Oncology & Cancer Science - Pharmaceutical Sciences

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endometriosis

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