Endometriosis

Bulun Se, Serdar E. Bulun
New England Journal of Medicine · 2009 · vol. 360(3) , pp. 268–279 · doi:10.1056/nejmra0804690 · PMID:19144942 · W4231488642
Review OA: closed CC0 ⤵ 1389 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This review highlights the roles of estrogen and inflammation, driven by a feedback cycle involving prostaglandins and aromatase, in the development and persistence of endometriotic tissue.

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Abstract

This review emphasizes the participation of estrogen and inflammation in the development of endometriosis. A feedback cycle in which prostaglandins and aromatase activity are prominent allows for the persistence of endometriotic tissue. Knowledge of this cycle has important implications for the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogens Prostaglandins DNA Methylation DNA Methylation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Epigenesis, Genetic Epigenesis, Genetic Estrogens Estrogens Female Female Gene Expression Profiling Gene Expression Profiling Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (90)

Cited by (50)

Source provenance

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License: CC0 · commercial use OK