Detailed analysis of a randomized, multicenter, comparative trial of dienogest versus leuprolide acetate in endometriosis
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⤵ 79 in-corpus citations
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Dienogest demonstrated non-inferior efficacy to leuprolide acetate for endometriosis pain relief and symptom improvement, with superior quality-of-life outcomes and a favorable safety profile.
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Abstract
OBJECTIVE: To analyze the secondary efficacy and safety outcomes from a recent trial comparing dienogest (DNG) with leuprolide acetate (LA) in women with endometriosis.
METHODS: A 24-week, open-label, randomized, multicenter study of DNG versus LA in women with endometriosis-related pain was assessed for outcomes such as responder rates (using predefined thresholds of pain relief), changes in single symptoms/signs and sum scores from the Biberoglu and Behrman (B&B) scale, clinical laboratory parameters, and measures of quality of life.
RESULTS: Dienogest was non-inferior to LA for treatment response using all predefined thresholds of pain relief and provided equivalent improvements in B&B symptoms and signs. No clinically relevant changes in laboratory parameters were observed during DNG treatment, whereas estrogen levels decreased in the LA group. Compared with LA, DNG was associated with pronounced improvements in specific quality-of-life measures.
CONCLUSION: The analyses provide supportive evidence that the efficacy of DNG is equivalent to that of LA for treating endometriosis symptoms, with specific quality-of-life benefits and a favorable safety profile.
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- THERAPEUTIC OPTIONS IN ENDOMETRIOSIS: A COMPARATIVE LITERATURE REVIEW OF INTRAUTERINE DEVICE THERAPY, SURGICAL TREATMENT, RELUGOLIX COMBINATION THERAPY, AND DIENOGEST 2026
- Dual therapeutic role of dienogest and vitamin E in endometriosis management and cardiovascular risk modulation; a narrative review study 2026
- The effects of melatonin on endometriosis-associated pain and regression of endometrioma; a triple blind randomized controlled trial 2025
- Hormonal Treatment of Endometriosis: A Narrative Review 2025
- Progestagens for pain symptoms associated with endometriosis 2025
- A systematic literature review on patient-reported outcome domains and measures in nonsurgical efficacy trials related to chronic pain associated with endometriosis: an urgent call to action 2024
- Dienogest in conjunction with GnRH-a for postoperative management of endometriosis 2024
- Safety and efficacy of pharmacotherapies for pelvic inflammatory disease and endometriosis 2024
- Endometriose 2024
- Dienogest versus gonadotropin-releasing hormone analogues for the clinical treatment of endometriosis: an updated meta-analysis 2024
- Superficial Peritoneal Endometriosis Vaporization Using a CO2 Laser: A Long-Term Single-Center Experience 2024
- Superficial Peritoneal Endometriosis Vaporization Using a CO2 Laser: a long-term single-center experience. 2024
- Medikamentöse Therapie der Endometriose – ein Update 2023
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- A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment 2023
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- The ENDOPAIN 4D Questionnaire: A New Validated Tool for Assessing Pain in Endometriosis 2021
- Advances in the medical treatment of adolescent endometriosis 2021
- Observational Study for Adverse Effects and Discontinuation with Long-Term Post-Operative Hormonal Treatment for Endometriosis in Real-World Practice 2021
- Short-term Efficacy of Dienogest in Improving Pain in Patients with Endometriosis: A Single-center Experience 2021
- Efficacy of dienogest vs combined oral contraceptive on pain associated with endometriosis: Randomized clinical trial 2021
- Dienogest vs GnRH agonists as postoperative therapy after laparoscopic eradication of deep infiltrating endometriosis with bowel and parametrial surgery: a randomized controlled trial 2021
- When and how should peritoneal endometriosis be operated on in order to improve fertility rates and symptoms? The experience and outcomes of nearly 100 cases 2021
- The effectiveness of therapy for endometriosis-associated pelvic pain resistant to surgical treatment 2021
- Medical Management of Endometriosis in Adolescents 2020
- Risk factors for non-response and discontinuation of Dienogest in endometriosis patients: A cohort study 2020
- Medical therapy options for endometriosis related pain, which is better? A systematic review and network meta-analysis of randomized controlled trials 2020
- Dysmenorrhea, Endometriosis and Chronic Pelvic Pain in Adolescents 2020
- Is Scientific Medical Literature Related to Endometriosis Treatment Evidence-Based? A Systematic Review on Methodological Quality of Randomized Clinical Trials 2019
- Comparison of long-term use of combined oral contraceptive after gonadotropin-releasing hormone agonist plus add-back therapy versus dienogest to prevent recurrence of ovarian endometrioma after surgery 2019
- Systematic review of quality of life measures in patients with endometriosis 2019
- Reviewing the role of progesterone therapy in endometriosis 2018
- Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries 2018
- Effect of Dienogest and the GnRH-a in Endometriosis: A Meta-Analysis 2018
- Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice 2018
- Tratamientos farmacológicos de la endometriosis (a excepción de la adenomiosis) 2018
- Efficacy and Safety of Long-Term Use of Dienogest in Women With Ovarian Endometrioma 2017
- Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment 2017
- Hormonal Therapy for Pelvic Pain 2017
- Progestins in the Medical Management of Endometriosis 2017
- The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clinical Trial 2017
- [Medical treatment of endometriosis: Hormonal treatment of pain, impact on evolution and future perspectives] 2017
- Dienogest for Treatment of Endometriosis in Chinese Women: A Placebo-Controlled, Randomized, Double-Blind Phase 3 Study 2017
- Dienogest versus gonadotropin-releasing hormone analogue for the clinical treatment of endometriosis: a systematic review and meta-analysis 2017
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- last seen: 2026-10-11T06:14:19.339412+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
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