Effect of Dienogest and the GnRH-a in Endometriosis: A Meta-Analysis

Objective The aim of this study is to systematically evaluate the efficacy and safety between dienogest and some GnRH-a while treating endometriosis. Methods The search was applied to Cochrane Library, EMBASE, PubMed, Web of Science, CNKI, WANFANG DATA, VIP and CBM database. All types of clinical study about dienogest and GnRH-a in endometriosis were included. All authors extracted data and assessed literature quality independently. Meta-analysis was conducted using RevM an software. Results Six studies included show that the efficiency of prevent uteruspain MD = 1.40(95% CI = 2.14–4.94, P = 4.94), the incidence of headache (OR = 0.75, 95%CI = 0.75–1.10, P = 0.14), and dienogest treatment of endometriosis in the possibility of hot flashes (OR = 0.18, 95% CI = 0.18–0.27, P < 0.00001) and the possibility of weight gain (OR = 0.74, 95% CI = 0.74–1.29, P = 0.29) than GnRH-a group of small, in contrast, use dienogest in the treatment of endometriosis with irregular bleeding possibility is larger than GnRH-a group (OR = 15.83, 95% CI = 15.83–30.82,P < 0.00001). Conclusion Compared the prevent uteruspain in treating endometriosis, dienogest and GnRH-a perform an analogous effect in prevent pain. But both could cause different degree of adverse reactions. Clinical medication should be depending upon the patients’ and clinical condition.