Moderate and severe endometriosis is associated with alterations in the cell cycle of granulosa cells in patients undergoing in vitro fertilization and embryo transfer

M Toya, Toya M, Mayumi Toya, H Saito, Saito H, Hidekazu Saito, N Ohta, Nobuhiko Ohta, Ohta N, T. Saito, Saito T, Takakazu Saito, Tomoko Kaneko-Tarui, Kaneko T, T Kaneko, Hiroi M, M Hiroi, Masahiko Hiroi
Fertility and sterility · 2000 · vol. 73(2) , pp. 344–350 · doi:10.1016/s0015-0282(99)00507-5 · PMID:10685541 · W2081108347
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This study investigated granulosa cell cycle alterations in patients undergoing IVF, finding associations between moderate and severe endometriosis and significant changes in these cells.

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Abstract

OBJECTIVE: To determine whether folliculogenesis is impaired in patients with endometriosis. DESIGN: Prospective study. SETTING: Yamagata University School of Medicine, Yamagata, Japan. PATIENT(S): Thirty women participating in an IVF program. INTERVENTION(S): The patients were divided into four groups according to the cause of their infertility: tubal factor (T), n = 7; male factor (M), n = 7; idiopathic (I), n = 7; and endometriosis (E), n = 9. Granulosa cells were obtained from the follicular fluid of each patient and analyzed by flow cytometry. MAIN OUTCOME MEASURE(S): The percentage of granulosa cells in each cell-cycle stage. RESULT(S): The mean (+/- SD) rate of apoptosis in the granulosa cells obtained from the patients with endometriosis was the highest among the four groups (T = 11.7% +/- 3.3%; M = 5.6% +/- 3.8%; I = 9.6% +/- 5.1%; and E = 18.6% +/- 9.6%). The percentage of S-phase granulosa cells was significantly higher in the patients with endometriosis than in all the other patients combined (E = 12.5% +/- 6%; T + M + I = 9.3% +/- 2.9%). The percentage of G2/M-phase granulosa cells was significantly lower in the endometriosis group than in the other three groups combined (E = 2.3% +/- 2.5%; T + M + I = 4.6% +/- 2.1%). CONCLUSION(S): Endometriosis impairs the cell cycle in granulosa cells. This phenomenon may have a detrimental effect on folliculogenesis.

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Condition tags

endometriosis

MeSH descriptors

Cell Cycle Cell Cycle Cell Cycle Endometriosis Fertilization in Vitro Fertilization in Vitro Granulosa Cells Infertility, Female Adult Adult Chorionic Gonadotropin Chorionic Gonadotropin Chorionic Gonadotropin DNA DNA DNA Endometriosis Endometriosis Endometriosis Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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