Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review

Hipólito-Reis M, Mariana Hipólito-Reis, Mariana Hipólito‐Reis, Ana Catarina Neto, Neto AC, Delminda Neves
Phytotherapy research : PTR · 2022 · vol. 36(6) , pp. 2416–2433 · doi:10.1002/ptr.7464 · PMID:35583746 · W4280590209
Systematic review / meta-analysis OA: closed CC0 ⤵ 14 in-corpus citations
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Curcumin, quercetin, and resveratrol demonstrated beneficial effects on endometriosis pathophysiology by influencing inflammation, oxidative stress, cell proliferation, and other mechanisms, suggesting potential therapeutic applications.

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Abstract

Endometriosis, a gynecological disease that affects reproductive age women is difficultly controlled in the long term by currently available treatments, prompting patients to adopt self-controlled interventions including dietary changes. The aim of this review is to provide evidence of how curcumin, quercetin, and resveratrol can act as natural interventions to control endometriosis. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search was carried out in PubMed, Scopus, and Web of Science to gather together all the articles that study the specific actions of curcumin, resveratrol, or quercetin in endometriosis pathophysiology. All types of study designs including experimental data were considered. Thirty articles, including a clinical trial, were included. For the assessment of the quality of the selected studies that globally have "good quality", the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used. By acting on mechanisms of inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis, angiogenesis and glucose and lipid metabolism, curcumin, quercetin, and resveratrol showed to have beneficial effects, evidencing their potential application in the endometriosis treatment. However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin Curcumin

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (58)

Cited by (18)

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