Ferroptosis in reproductive system disorders: Pathological roles and therapeutic potential

Shuai Guo; Shuai Wang; Cai Zhang; Xueying Wang; Shuaiqi Zhao; Siyuan Zhao

doi:10.1016/j.cellsig.2025.112218

Ferroptosis in reproductive system disorders: Pathological roles and therapeutic potential

Shuai Guo, Shuai Wang, Cai Zhang, Xueying Wang, Shuaiqi Zhao, Siyuan Zhao

Cellular signalling · 2025 · vol. 138 , pp. 112218 · doi:10.1016/j.cellsig.2025.112218 · PMID:41203186 · W4415939222

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Ferroptosis, an iron-dependent programmed cell death, contributes to polycystic ovary syndrome, endometriosis, and spermatogenic disorders, presenting a potential therapeutic target for reproductive system diseases.

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Abstract

Ferroptosis, as an iron-dependent programmed cell death, plays a significant role in reproductive system diseases. It's involved in the pathological processes of various reproductive system diseases by affecting the survival status of germ cells and the structure and function of reproductive tissues, including polycystic ovary syndrome, endometriosis and spermatogenic disorder. Researchers are actively exploring the therapeutic potential of ferroptosis in reproductive system diseases. Ferroptosis can serve as a potential therapeutic target for clinical treatment, which can be combined with existing therapies, allowing for personalized treatment plans based on patients' conditions. The study of ferroptosis not only provides a new perspective on the pathogenesis of reproductive system diseases, but also offers a theoretical basis for developing novel therapeutic drugs. With a deeper understanding of the ferroptosis mechanism, treatment strategies based on it are expected to become an important means of treating reproductive system diseases in the future. This will bring new hope for improving patients' reproductive health and enhancing their quality of life.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (68)

Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis via openalex
Endometriosis: The Role of Iron Overload and Ferroptosis via openalex
Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis via openalex
Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature via openalex
Fertility preservation in women with endometriosis via openalex
Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review via openalex
Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity via openalex
Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2 via openalex
The role of iron in the pathogenesis of endometriosis: a systematic review via openalex
doi:10.1530/joe-20-0155 via openalex
doi:10.1016/j.freeradbiomed.2020.07.026 via openalex
doi:10.1111/j.1365-2265.2007.02752.x via openalex
doi:10.1016/j.tox.2020.152489 via openalex
doi:10.1016/s0090-4295(96)00313-5 via openalex
doi:10.1210/en.2018-00731 via openalex
doi:10.1158/1541-7786.mcr-19-0691 via openalex
doi:10.1095/biolreprod.115.130989 via openalex
doi:10.1016/j.molmed.2018.07.004 via openalex
doi:10.1038/cdd.2015.158 via openalex
doi:10.1158/0008-5472.can-23-0285 via openalex
doi:10.3390/cells13171490 via openalex
doi:10.1186/s12958-024-01252-4 via openalex
doi:10.1038/s41419-025-07354-0 via openalex
doi:10.1186/s12951-022-01635-y via openalex
doi:10.1007/s00345-025-05637-x via openalex
doi:10.1016/j.cbi.2022.110148 via openalex
doi:10.1016/j.freeradbiomed.2022.10.314 via openalex
doi:10.1158/1541-7786.mcr-20-0534 via openalex
doi:10.7717/peerj.17842 via openalex
doi:10.1007/s10495-023-01850-4 via openalex
doi:10.2147/jir.s527722 via openalex
doi:10.1111/jog.14779 via openalex
doi:10.1186/s13287-022-03147-w via openalex
doi:10.1007/s00109-025-02528-x via openalex
doi:10.1016/j.phrs.2020.105157 via openalex
doi:10.1155/2023/4952857 via openalex
doi:10.1155/2022/6833867 via openalex
doi:10.1016/j.redox.2021.102227 via openalex
doi:10.1016/j.redox.2024.103350 via openalex
doi:10.1007/s00432-023-05267-z via openalex
doi:10.1007/s00210-024-03440-w via openalex
doi:10.1097/cm9.0000000000003126 via openalex
doi:10.1016/j.bioorg.2024.107174 via openalex
doi:10.3390/ijms23137139 via openalex
doi:10.4103/aja202266 via openalex
doi:10.3390/antiox13070791 via openalex
doi:10.1155/2020/3469840 via openalex
doi:10.1016/j.tox.2021.153050 via openalex
doi:10.3389/fendo.2023.1324429 via openalex
doi:10.3389/fcell.2025.1563353 via openalex
doi:10.1038/s41420-023-01713-6 via openalex
doi:10.1016/j.redox.2024.103298 via openalex
doi:10.1242/dev.201157 via openalex
doi:10.1186/s12951-024-02496-3 via openalex
doi:10.1007/s00441-022-03664-3 via openalex
doi:10.3389/fendo.2023.1070264 via openalex
doi:10.1016/j.theriogenology.2021.01.007 via openalex
doi:10.1038/s41420-024-02013-3 via openalex
doi:10.3389/fendo.2024.1452219 via openalex
doi:10.1007/s12011-024-04473-1 via openalex
doi:10.1152/japplphysiol.00583.2022 via openalex
doi:10.1080/15384047.2023.2291855 via openalex
doi:10.1016/j.redox.2021.101928 via openalex
doi:10.1002/jbt.70158 via openalex
doi:10.2174/1574892818666221103114649 via openalex
doi:10.3389/fvets.2025.1526474 via openalex
doi:10.1007/s11010-020-03821-8 via openalex
doi:10.1002/tox.24304 via openalex

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License: CC0 · commercial use OK

[1] Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis via openalex

[2] Endometriosis: The Role of Iron Overload and Ferroptosis via openalex

[3] Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis via openalex

[4] Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature via openalex

[5] Fertility preservation in women with endometriosis via openalex

[6] Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review via openalex

[7] Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity via openalex

[8] Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2 via openalex

[9] The role of iron in the pathogenesis of endometriosis: a systematic review via openalex

[10] doi:10.1530/joe-20-0155 via openalex

[11] doi:10.1016/j.freeradbiomed.2020.07.026 via openalex

[12] doi:10.1111/j.1365-2265.2007.02752.x via openalex

[13] doi:10.1016/j.tox.2020.152489 via openalex

[14] doi:10.1016/s0090-4295(96)00313-5 via openalex

[15] doi:10.1210/en.2018-00731 via openalex

[16] doi:10.1158/1541-7786.mcr-19-0691 via openalex

[17] doi:10.1095/biolreprod.115.130989 via openalex

[18] doi:10.1016/j.molmed.2018.07.004 via openalex

[19] doi:10.1038/cdd.2015.158 via openalex

[20] doi:10.1158/0008-5472.can-23-0285 via openalex

[21] doi:10.3390/cells13171490 via openalex

[22] doi:10.1186/s12958-024-01252-4 via openalex

[23] doi:10.1038/s41419-025-07354-0 via openalex

[24] doi:10.1186/s12951-022-01635-y via openalex

[25] doi:10.1007/s00345-025-05637-x via openalex

[26] doi:10.1016/j.cbi.2022.110148 via openalex

[27] doi:10.1016/j.freeradbiomed.2022.10.314 via openalex

[28] doi:10.1158/1541-7786.mcr-20-0534 via openalex

[29] doi:10.7717/peerj.17842 via openalex

[30] doi:10.1007/s10495-023-01850-4 via openalex

[31] doi:10.2147/jir.s527722 via openalex

[32] doi:10.1111/jog.14779 via openalex

[33] doi:10.1186/s13287-022-03147-w via openalex

[34] doi:10.1007/s00109-025-02528-x via openalex

[35] doi:10.1016/j.phrs.2020.105157 via openalex

[36] doi:10.1155/2023/4952857 via openalex

[37] doi:10.1155/2022/6833867 via openalex

[38] doi:10.1016/j.redox.2021.102227 via openalex

[39] doi:10.1016/j.redox.2024.103350 via openalex

[40] doi:10.1007/s00432-023-05267-z via openalex

[41] doi:10.1007/s00210-024-03440-w via openalex

[42] doi:10.1097/cm9.0000000000003126 via openalex

[43] doi:10.1016/j.bioorg.2024.107174 via openalex

[44] doi:10.3390/ijms23137139 via openalex

[45] doi:10.4103/aja202266 via openalex

[46] doi:10.3390/antiox13070791 via openalex

[47] doi:10.1155/2020/3469840 via openalex

[48] doi:10.1016/j.tox.2021.153050 via openalex

[49] doi:10.3389/fendo.2023.1324429 via openalex

[50] doi:10.3389/fcell.2025.1563353 via openalex

[51] doi:10.1038/s41420-023-01713-6 via openalex

[52] doi:10.1016/j.redox.2024.103298 via openalex

[53] doi:10.1242/dev.201157 via openalex

[54] doi:10.1186/s12951-024-02496-3 via openalex

[55] doi:10.1007/s00441-022-03664-3 via openalex

[56] doi:10.3389/fendo.2023.1070264 via openalex

[57] doi:10.1016/j.theriogenology.2021.01.007 via openalex

[58] doi:10.1038/s41420-024-02013-3 via openalex

[59] doi:10.3389/fendo.2024.1452219 via openalex

[60] doi:10.1007/s12011-024-04473-1 via openalex

[61] doi:10.1152/japplphysiol.00583.2022 via openalex

[62] doi:10.1080/15384047.2023.2291855 via openalex

[63] doi:10.1016/j.redox.2021.101928 via openalex

[64] doi:10.1002/jbt.70158 via openalex

[65] doi:10.2174/1574892818666221103114649 via openalex

[66] doi:10.3389/fvets.2025.1526474 via openalex

[67] doi:10.1007/s11010-020-03821-8 via openalex

[68] doi:10.1002/tox.24304 via openalex