Ferroptosis in reproductive system disorders: Pathological roles and therapeutic potential

Guo S; Shuai Guo; Wang S; Shuai Wang; Zhang C; Cai Zhang; Wang X; Xueying Wang; Zhao S; Shuaiqi Zhao; Siyuan Zhao

doi:10.1016/j.cellsig.2025.112218

Ferroptosis in reproductive system disorders: Pathological roles and therapeutic potential

Guo S, Shuai Guo, Wang S, Shuai Wang, Zhang C, Cai Zhang, Wang X, Xueying Wang, Zhao S, Shuaiqi Zhao, Siyuan Zhao

Cellular signalling · 2025 · vol. 138 , pp. 112218 · doi:10.1016/j.cellsig.2025.112218 · PMID:41203186 · W4415939222

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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Ferroptosis, an iron-dependent programmed cell death, contributes to polycystic ovary syndrome, endometriosis, and spermatogenic disorders, presenting a potential therapeutic target for reproductive system diseases.

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Abstract

Ferroptosis, as an iron-dependent programmed cell death, plays a significant role in reproductive system diseases. It's involved in the pathological processes of various reproductive system diseases by affecting the survival status of germ cells and the structure and function of reproductive tissues, including polycystic ovary syndrome, endometriosis and spermatogenic disorder. Researchers are actively exploring the therapeutic potential of ferroptosis in reproductive system diseases. Ferroptosis can serve as a potential therapeutic target for clinical treatment, which can be combined with existing therapies, allowing for personalized treatment plans based on patients' conditions. The study of ferroptosis not only provides a new perspective on the pathogenesis of reproductive system diseases, but also offers a theoretical basis for developing novel therapeutic drugs. With a deeper understanding of the ferroptosis mechanism, treatment strategies based on it are expected to become an important means of treating reproductive system diseases in the future. This will bring new hope for improving patients' reproductive health and enhancing their quality of life.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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License: CC0 · commercial use OK

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[2] Endometriosis: The Role of Iron Overload and Ferroptosis via openalex

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