Levels of transferrin and alpha 2-HS glycoprotein in women with and without endometriosis

Subbi Mathur, Mathur SP, S P Mathur, Lee JH, J H Lee, Jong Hoon Lee, H Jiang, Jiang H, Haixiang Jiang, Philippe Arnaúd, Arnaud P, P Arnaud, P. F. Rust, Philip F. Rust, Rust PF
Autoimmunity · 1999 · vol. 29(2) , pp. 121–127 · doi:10.3109/08916939908995381 · PMID:10433073 · W2129138789
Observational OA: closed CC0 ⤵ 27 in-corpus citations
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This study found elevated transferrin and alpha 2-HS glycoprotein in the peritoneal fluid of women with endometriosis compared to controls, suggesting a role in the condition's autoimmune pathophysiology.

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Abstract

The study objective was to test the hypothesis that elevated levels of transferrin and alpha 2-HS glycoprotein occur in the peritoneal environment of patients with endometriosis that may lead to the observed autoimmunity to these proteins. We set up a double sandwich enzyme-linked immunosorbent assay (ELISA) for measuring levels of transferrin and alpha 2-HS glycoprotein in the serum and peritoneal fluid samples from women with (n = 24-60) and without endometriosis (n = 35-49). Serum and peritoneal fluid levels of alpha 2-HS glycoprotein and peritoneal fluid levels of transferrin were significantly elevated in patients with endometriosis, in contrast to the controls. Serum levels of transferrin in patients, however, were significantly less in the patients than in controls. We conclude that transferrin and alpha 2-HS glycoprotein are present at high concentrations in the peritoneal fluids of patients with endometriosis. This may play a significant role in the autoimmune pathophysiology of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Blood Proteins Endometriosis Transferrin alpha-2-HS-Glycoprotein alpha-2-HS-Glycoprotein Ascitic Fluid Ascitic Fluid Ascitic Fluid Autoimmunity Autoimmunity Blood Proteins Blood Proteins Endometriosis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (27)

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