Angiogenic activity of peritoneal fluid from women with endometriosis

D J Oosterlynck, Oosterlynck DJ, Didier J. Oosterlynck, C Meuleman, Christel Meuleman, Meuleman C, H. Sobis, Sobis H, Vandeputte M, Michel Vandeputte, M Vandeputte, P R Koninckx, Philippe R. Koninckx, Koninckx PR
Fertility and sterility · 1993 · vol. 59(4) , pp. 778–782 · doi:10.1016/s0015-0282(16)55859-2 · PMID:8458496 · W2404389558
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This study investigated the angiogenic activity of peritoneal fluid collected from women with endometriosis.

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Abstract

OBJECTIVE: To investigate the presence of angiogenic factors in peritoneal fluid (PF) and follicular fluid (FF). DESIGN: The PF samples of 48 women with (n = 24) or without (n = 24) endometriosis were investigated. Angiogenesis was assayed using the chorioallantoic membrane of 11-day-old fertilized chicken embryos. Glass fiber prefilters impregnated with the fluids were placed on the chorioallantoic membrane. MAIN OUTCOME MEASURE: The vascular reaction was analyzed by an independent observer after 72 hours. RESULTS: There was a positive reaction in 58.3% of the PF from women with endometriosis and in 12.5% of the women without endometriosis. No correlation was found between the angiogenic response and the severity of endometriosis. The reaction remained after charcoal treatment of the PF. Positive reaction was found in three of six FF samples. CONCLUSION: The PF of women with endometriosis contain more angiogenic factors than PF from women without endometriosis. This angiogenic activity could be important for the further outgrowth and progression of the lesions.

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Condition tags

endometriosis

MeSH descriptors

Angiogenesis Inducing Agents Ascitic Fluid Endometriosis Angiogenesis Inducing Agents Angiogenesis Inducing Agents Animals Animals Ascitic Fluid Ascitic Fluid Biological Assay Biological Assay Chick Embryo Chick Embryo Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (21)

Cited by (50)

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